caa a22 4500 47576787X CHVBK 20180406123611.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s004270000107 doi (NATIONALLICENCE)springer-10.1007/s004270000107 Quantitative developmental genetic analysis reveals that the ancestral dipteran wing vein prepattern is conserved in Drosophila melanogaster [Elektronische Daten] [Arnar Palsson, G. Gibson] Abstract : Quantitative complementation tests provide a quick test of the hypothesis that a particular gene contributes to segregating phenotypic variation. A set of wild-type alleles is assayed for variation in their ability to complement the degree of dominance of the quantitative effect of a loss of function allele. Analysis of 15 loci known to be involved in wing patterning in Drosophila melanogaster suggests that the genes decapentaplegic, thickveins, EGFR, argos and hedgehog, each of which are involved in secreted growth factor signaling, may contribute to wing shape variation. The phenotype of one deficiency, Df(2R)Px2, which removes blistered/Plexate, is also highly sensitive to the wild-type genetic background and at intermediate expressivity reveals six ectopic veins. These form in the same locations as a projection of the ancestral pattern of dipteran wing veins onto the D. melanogaster wing. This atavistic phenotype indicates that the wing vein prepatterning mechanism can be conserved in highly derived species, and implies that homoplasic venation patterns may be produced by derepression of vein primordia. Springer-Verlag Berlin Heidelberg, 2000 Keywords Quantitative complementation test nationallicence Relative warp analysis nationallicence Atavistic nationallicence EGFR nationallicence TGF-β nationallicence Palsson Arnar Department of Genetics, North Carolina State University, Raleigh, NC 27695-7614, USA e-mail: ggibson@unity.ncsu.edu Tel.: +1-919-5132512, Fax: +1-919-5153355, US aut Gibson G. Department of Genetics, North Carolina State University, Raleigh, NC 27695-7614, USA e-mail: ggibson@unity.ncsu.edu Tel.: +1-919-5132512, Fax: +1-919-5153355, US aut https://doi.org/10.1007/s004270000107 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270000107 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Palsson Arnar Department of Genetics, North Carolina State University, Raleigh, NC 27695-7614, USA e-mail: ggibson@unity.ncsu.edu Tel.: +1-919-5132512, Fax: +1-919-5153355, US aut NATIONALLICENCE 700 1- Gibson G. Department of Genetics, North Carolina State University, Raleigh, NC 27695-7614, USA e-mail: ggibson@unity.ncsu.edu Tel.: +1-919-5132512, Fax: +1-919-5153355, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer