caa a22 4500 475768019 CHVBK 20180406123611.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004270000084 doi (NATIONALLICENCE)springer-10.1007/s004270000084 An IQGAP-related gene is activated during tentacle formation in the simple metazoan Hydra [Elektronische Daten] [Caterina R. Venturelli, Sergej Kuznetsov, Luis M. Salgado, T. C. G. Bosch] Abstract : Differentiation of body column epithelial cells into tentacle epithelial cells in Hydra is accompanied by changes in both cell shape and cell-cell contact. The molecular mechanism by which epithelial cells acquire tentacle cell characteristics is unknown. Here we report that expression of a Hydra homologue of the mammalian IQGAP1 protein is strongly upregulated during tentacle formation. Like mammalian IQGAP, Hydra IQGAP1 contains an N-terminal calponin-homology domain, IQ repeats and a conserved C terminus. In adult polyps a high level of Hydra IQGAP1 mRNA is detected at the basis of tentacles. Consistent with a role in tentacle formation, IQGAP1 expression is activated during head regeneration and budding at a time when tentacles are emerging. The observations support the previous hypothesis that IQGAP proteins are involved in cytoskeletal as well as cell-cell contact rearrangements. Springer-Verlag Berlin Heidelberg, 2000 Key words Cnidaria nationallicence IQGAP nationallicence Hydra nationallicence Cytoskeleton nationallicence Regeneration nationallicence Venturelli Caterina R. CINVESTAV-IPN, Dept. Genetica, 07000 Mexico, MX aut Kuznetsov Sergej Institut für Spezielle Zoologie und Evolutionsbiologie, Universität Jena, Erbertstrasse 1, 07743 Jena, Germany, E-mail: tbosch@zoologie.uni-kiel.de Tel: +49-431-8804169, Fax: +49-431-8804747, DE aut Salgado Luis M. CINVESTAV-IPN, Dept. Bioquimica, 07000 Mexico, MX aut Bosch T. C. G. Institut für Spezielle Zoologie und Evolutionsbiologie, Universität Jena, Erbertstrasse 1, 07743 Jena, Germany, E-mail: tbosch@zoologie.uni-kiel.de Tel: +49-431-8804169, Fax: +49-431-8804747, DE aut https://doi.org/10.1007/s004270000084 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270000084 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Venturelli Caterina R. CINVESTAV-IPN, Dept. Genetica, 07000 Mexico, MX aut NATIONALLICENCE 700 1- Kuznetsov Sergej Institut für Spezielle Zoologie und Evolutionsbiologie, Universität Jena, Erbertstrasse 1, 07743 Jena, Germany, E-mail: tbosch@zoologie.uni-kiel.de Tel: +49-431-8804169, Fax: +49-431-8804747, DE aut NATIONALLICENCE 700 1- Salgado Luis M. CINVESTAV-IPN, Dept. Bioquimica, 07000 Mexico, MX aut NATIONALLICENCE 700 1- Bosch T. C. G. Institut für Spezielle Zoologie und Evolutionsbiologie, Universität Jena, Erbertstrasse 1, 07743 Jena, Germany, E-mail: tbosch@zoologie.uni-kiel.de Tel: +49-431-8804169, Fax: +49-431-8804747, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer