caa a22 4500 475768035 CHVBK 20180406123611.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004270000077 doi (NATIONALLICENCE)springer-10.1007/s004270000077 Expression and subcellular localization of X-ATM during early Xenopus development [Elektronische Daten] [Carmel Hensey, Kirsten Robertson, J. Gautier] Abstract : ATM, the gene mutated in ataxia telangiectasia, is a protein essential for handling DNA strand breaks. We recently isolated the Xenopus homologue of ATM, X-ATM and we report here the detailed expression pattern of the protein and the mRNA during early Xenopus development. During the cleavage stages, ATM protein was concentrated in and around the nuclei of all cells with low levels of expression also detected in the cytoplasm. Following neurulation, increased protein levels were detected in the nuclei of developing somites and in the central nervous system. Areas of high protein expression correlated with areas of increased mRNA expression which was detected in the nuclei of somites and the developing lens. Springer-Verlag Berlin Heidelberg, 2000 Key words Ataxia Telangiectasia nationallicence ATM nationallicence Xenopus nationallicence Lens nationallicence Somites nationallicence Hensey Carmel Department of Genetics and Development and Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 W 168 St., New York, NY 10032, USA E-mail: jg130@columbia.edu Tel.: +1-212-3059586, Fax: +1-212-3057391, US aut Robertson Kirsten Department of Genetics and Development and Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 W 168 St., New York, NY 10032, USA E-mail: jg130@columbia.edu Tel.: +1-212-3059586, Fax: +1-212-3057391, US aut Gautier J. Department of Genetics and Development and Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 W 168 St., New York, NY 10032, USA E-mail: jg130@columbia.edu Tel.: +1-212-3059586, Fax: +1-212-3057391, US aut https://doi.org/10.1007/s004270000077 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270000077 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hensey Carmel Department of Genetics and Development and Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 W 168 St., New York, NY 10032, USA E-mail: jg130@columbia.edu Tel.: +1-212-3059586, Fax: +1-212-3057391, US aut NATIONALLICENCE 700 1- Robertson Kirsten Department of Genetics and Development and Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 W 168 St., New York, NY 10032, USA E-mail: jg130@columbia.edu Tel.: +1-212-3059586, Fax: +1-212-3057391, US aut NATIONALLICENCE 700 1- Gautier J. Department of Genetics and Development and Department of Dermatology, College of Physicians and Surgeons of Columbia University, 630 W 168 St., New York, NY 10032, USA E-mail: jg130@columbia.edu Tel.: +1-212-3059586, Fax: +1-212-3057391, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer