caa a22 4500 47576806X CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004270050022 doi (NATIONALLICENCE)springer-10.1007/s004270050022 The HOX-like gene Cnox2-Pc is expressed at the anterior region in all life cycle stages of the jellyfish Podocoryne carnea [Elektronische Daten] [L. M. Masuda-Nakagawa, H. Gröer, B. L. Aerne, V. Schmid] Abstract : The marine jellyfish Podocoryne carnea (Cnidaria, Hydrozoa) has a metagenic life cycle consisting of a larva, a colonial polyp and a free-swimming jellyfish (medusa). To study the function of HOX genes in primitive diploblastic animals we screened a library of P. carnea cDNA using PCR primers derived from the most conserved regions in helix 1 and helix 3 of the homeobox. A novel gene, Cnox2-Pc, has been isolated and characterized. Cnox2-Pc is a HOX cluster-like gene, and its homeodomain shows similarity to the Deformed subfamily of HOM-C/HOX genes. In situ hybridization revealed that Cnox2-Pc is expressed in the anterior region of the larva, the polyp head, and the most apical ectoderm of the differentiating bud during medusa development. In adult medusa expression is restricted to the gastrovascular entoderm. The results suggest that Cnox2-Pc is involved in establishment of an anterior-posterior axis during development in primitive metazoans. Springer-Verlag Berlin Heidelberg, 2000 Key words Homeobox genes nationallicence Cnidaria nationallicence Podocoryne carnea nationallicence Masuda-Nakagawa L. M. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut Gröer H. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut Aerne B. L. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut Schmid V. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut https://doi.org/10.1007/s004270050022 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050022 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Masuda-Nakagawa L. M. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut NATIONALLICENCE 700 1- Gröer H. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut NATIONALLICENCE 700 1- Aerne B. L. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut NATIONALLICENCE 700 1- Schmid V. Institute of Zoology, University of Basel, Rheinsprung 9, 4051 Basel, Switzerland, CH aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer