caa a22 4500 475768078 CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004270050023 doi (NATIONALLICENCE)springer-10.1007/s004270050023 Analysis of a swallow homologue from Drosophila pseudoobscura [Elektronische Daten] [Z. Huang, N. J. Pokrywka, J. H. Yoder, E. C. Stephenson] Abstract : We analyzed a functional homologue of the swallow gene from Drosophila pseudoobscura. The swallow gene of D. melanogaster plays an essential role in localizing bicoid mRNA in oocytes, and swallow mutant embryos show anterior pattern defects that result from the lack of localization of the bicoid morphogen. The pseudoobscura homologue rescues the function of swallow mutants when introduced into the genome of D. melanogaster, and its expression is similar to that of the melanogaster gene. The predicted pseudoobscura and melanogaster proteins are 49% identical and 69% conserved. The coiled-coil domain previously identified in the melanogaster swallow protein is strongly conserved in the pseudoobscura homologue, but the weak similarity of the melanogaster swallow protein to the RNP class of RNA-binding proteins is not conserved in the pseudoobscura homologue. These and other observations suggest a structural role for swallow in localizing bicoid mRNA, perhaps as part of the egg cytoskeleton. Springer-Verlag Berlin Heidelberg, 2000 Key words Swallow nationallicence bicoid nationallicence Drosophila nationallicence mRNA localization nationallicence Oogenesis nationallicence Embryogenesis nationallicence Huang Z. Department of Biological Sciences, Coalition for Biomolecular Products, Box 870344, University of Alabama, Tuscaloosa, AL 35487-0344, USA E-mail: estephen@biology.as.ua.edu Tel.: +1-205-3481828, Fax: +1-205-3481786, US aut Pokrywka N. J. Department of Biology, Vassar College, Poughkeepsie, NY 12604, USA, US aut Yoder J. H. Department of Biological Sciences, Coalition for Biomolecular Products, Box 870344, University of Alabama, Tuscaloosa, AL 35487-0344, USA E-mail: estephen@biology.as.ua.edu Tel.: +1-205-3481828, Fax: +1-205-3481786, US aut Stephenson E. C. Department of Biological Sciences, Coalition for Biomolecular Products, Box 870344, University of Alabama, Tuscaloosa, AL 35487-0344, USA E-mail: estephen@biology.as.ua.edu Tel.: +1-205-3481828, Fax: +1-205-3481786, US aut https://doi.org/10.1007/s004270050023 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050023 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Z. Department of Biological Sciences, Coalition for Biomolecular Products, Box 870344, University of Alabama, Tuscaloosa, AL 35487-0344, USA E-mail: estephen@biology.as.ua.edu Tel.: +1-205-3481828, Fax: +1-205-3481786, US aut NATIONALLICENCE 700 1- Pokrywka N. J. Department of Biology, Vassar College, Poughkeepsie, NY 12604, USA, US aut NATIONALLICENCE 700 1- Yoder J. H. Department of Biological Sciences, Coalition for Biomolecular Products, Box 870344, University of Alabama, Tuscaloosa, AL 35487-0344, USA E-mail: estephen@biology.as.ua.edu Tel.: +1-205-3481828, Fax: +1-205-3481786, US aut NATIONALLICENCE 700 1- Stephenson E. C. Department of Biological Sciences, Coalition for Biomolecular Products, Box 870344, University of Alabama, Tuscaloosa, AL 35487-0344, USA E-mail: estephen@biology.as.ua.edu Tel.: +1-205-3481828, Fax: +1-205-3481786, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer