caa a22 4500 475768086 CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004270050020 doi (NATIONALLICENCE)springer-10.1007/s004270050020 Distinct expression patterns for two Xenopus Bar homeobox genes [Elektronische Daten] [K. D. Patterson, O. Cleaver, W. V. Gerber, F. G. White, P. A. Krieg] Abstract : The BarH1 and BarH2 homeobox genes are coexpressed in cells of the fly retina and in the central and peripheral nervous systems. The fly Bar genes are required for normal development of the eye and external sensory organs. In Xenopus we have identified two distinct vertebrate Bar-related homeobox genes, XBH1 and XBH2. XBH1 is highly related in sequence and expression pattern to a mammalian gene, MBH1, suggesting that they are orthologues. XBH2 has not previously been identified but is clearly related to the Drosophila Bar genes. During early Xenopus embryogenesis XBH1 and XBH2 are expressed in overlapping regions of the central nervous system. XBH1, but not XBH2, is expressed in the developing retina. By comparing the expression of XBH1 with that of hermes, a marker of differentiated retinal ganglion cells, we show that XBH1 is expressed in retinal ganglion cells during the differentiation process, but is down-regulated as cells become terminally differentiated. Springer-Verlag Berlin Heidelberg, 2000 Key words Bar homeodomain protein nationallicence Gene expression nationallicence Eye development nationallicence Patterson K. D. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut Cleaver O. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut Gerber W. V. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut White F. G. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut Krieg P. A. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut https://doi.org/10.1007/s004270050020 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050020 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Patterson K. D. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut NATIONALLICENCE 700 1- Cleaver O. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut NATIONALLICENCE 700 1- Gerber W. V. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut NATIONALLICENCE 700 1- White F. G. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut NATIONALLICENCE 700 1- Krieg P. A. Division of Molecular Cell and Developmental Biology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer