caa a22 4500 475768116 CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s004270050017 doi (NATIONALLICENCE)springer-10.1007/s004270050017 DWnt-4 and Wingless have distinct activities in the Drosophila dorsal epidermis [Elektronische Daten] [M. A. Buratovich, S. Anderson, K. Gieseler, J. Pradel, E. L. Wilder] Abstract : Wnt genes are often expressed in overlapping patterns, where they affect a wide array of developmental processes. To address the way in which various Wnt signals elicit distinct effects we compared the activities of two Wnt genes in Drosophila, DWnt-4, and wingless. We show that these Wnt signals produce distinct responses in cells of the dorsal embryonic epidermis. Whereas wingless acts independently of hedgehog signaling in these cells, we show that DWnt-4 requires Hh to elicit its effects. We also show that expression of Wg signal transduction components does not mimic expression of DWnt-4, suggesting that DWnt-4 signaling proceeds through a distinct pathway. The dorsal epidermis may therefore be useful in the identification of novel Wnt signaling components. Springer-Verlag Berlin Heidelberg, 2000 Key words DWnt-4 nationallicence Wingless nationallicence Wnt signaling nationallicence Embryonic pattern formation nationallicence Hedgehog nationallicence Buratovich M. A. Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA E-mail: wildere@mail.med.upenn.edu Tel.: +1-215-8987805 Fax: +1-215-5737149, US aut Anderson S. Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA E-mail: wildere@mail.med.upenn.edu Tel.: +1-215-8987805 Fax: +1-215-5737149, US aut Gieseler K. Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France, FR aut Pradel J. Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France, FR aut Wilder E. L. Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA E-mail: wildere@mail.med.upenn.edu Tel.: +1-215-8987805 Fax: +1-215-5737149, US aut https://doi.org/10.1007/s004270050017 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050017 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Buratovich M. A. Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA E-mail: wildere@mail.med.upenn.edu Tel.: +1-215-8987805 Fax: +1-215-5737149, US aut NATIONALLICENCE 700 1- Anderson S. Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA E-mail: wildere@mail.med.upenn.edu Tel.: +1-215-8987805 Fax: +1-215-5737149, US aut NATIONALLICENCE 700 1- Gieseler K. Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France, FR aut NATIONALLICENCE 700 1- Pradel J. Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France, FR aut NATIONALLICENCE 700 1- Wilder E. L. Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA E-mail: wildere@mail.med.upenn.edu Tel.: +1-215-8987805 Fax: +1-215-5737149, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer