caa a22 4500 475768167 CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s004270000093 doi (NATIONALLICENCE)springer-10.1007/s004270000093 Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions [Elektronische Daten] [M. M. Lu, F. Chen, A. Gitler, J. Li, F. Jin, X. K. Ma, J. A. Epstein] Abstract : We describe here the first full-length sequence of a member of a novel gene family encoding a protein in the mouse that we call Lupin. Lupin is homologous to a human protein previously called p36, which was purified from α-interferon-treated cells that formed lupus inclusions. Lupus inclusions are dense intracellular deposits found in endothelial cells and lymphocytes of patients with systemic lupus erythematosis and AIDS. Proteins closely related to Lupin exist in evolutionarily divergent species including Caenorhabditis elegans, Drosophila and zebrafish. At least one other lupin-related gene is expressed in the mouse and in man. Lupin is expressed in mouse embryos and adults, notably in liver, spleen, central nervous system, multiple epithelia and all types of muscle. In skeletal muscle, expression analysis suggests that Lupin associates with the contractile apparatus. Springer-Verlag Berlin Heidelberg, 2000 Key words Systemic lupus erythematosis nationallicence AIDS nationallicence HIV nationallicence p36 nationallicence Cytoplasmic inclusion nationallicence Lu M. M. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut Chen F. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut Gitler A. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut Li J. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut Jin F. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut Ma X. K. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut Epstein J. A. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut https://doi.org/10.1007/s004270000093 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270000093 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lu M. M. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut NATIONALLICENCE 700 1- Chen F. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut NATIONALLICENCE 700 1- Gitler A. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut NATIONALLICENCE 700 1- Li J. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut NATIONALLICENCE 700 1- Jin F. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut NATIONALLICENCE 700 1- Ma X. K. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut NATIONALLICENCE 700 1- Epstein J. A. Cardiology Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II, 421 Curie Blvd, Philadelphia, PA 19104, USA e-mail: epsteinj@mail.med.upenn.edu Tel.: +1-215-8988731, Fax: +1-215-5732094, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer