caa a22 4500 475768175 CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s004270000092 doi (NATIONALLICENCE)springer-10.1007/s004270000092 An amphioxus Krox gene: insights into vertebrate hindbrain evolution [Elektronische Daten] [R. D. Knight, G. D. Panopoulou, P. W. H. Holland, S. M. Shimeld] Abstract : The transcription factor Krox-20 has roles in the maintenance of segmentation and specification of segment identity in the vertebrate hindbrain. Overt hindbrain segmentation is a vertebrate novelty, and is not seen in invertebrate chordates such as amphioxus and tunicates. To test if the roles of Krox-20 are also derived, we cloned a Krox-20 related gene, AmphiKrox, from amphioxus. AmphiKrox is related to a small family of vertebrate Krox genes and is expressed in the most anterior region of the amphioxus brain and in the club shaped gland, a secretory organ that develops in the anterior pharynx. Neither expression domain overlaps with the expression of AmphiHox-1, -2, -3 or -4, suggesting that the roles of Krox-20 in hindbrain segmentation and in Hox gene regulation were acquired concomitant with the duplication of Krox genes in vertebrate evolution. Springer-Verlag Berlin Heidelberg, 2000 Key words Krox-20 nationallicence Hox nationallicence amphioxus nationallicence Hindbrain nationallicence Vertebrate evolution nationallicence Knight R. D. School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK e-mail: s.m.shimeld@reading.ac.uk Tel.: +44-118-9875123 ext. 7084, Fax: +44-118-9310180, GB aut Panopoulou G. D. Max-Planck-Institut für Molekulare Genetik, 14195 Berlin-Dahlem, Germany, DE aut Holland P. W. H. School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK e-mail: s.m.shimeld@reading.ac.uk Tel.: +44-118-9875123 ext. 7084, Fax: +44-118-9310180, GB aut Shimeld S. M. School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK e-mail: s.m.shimeld@reading.ac.uk Tel.: +44-118-9875123 ext. 7084, Fax: +44-118-9310180, GB aut https://doi.org/10.1007/s004270000092 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270000092 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Knight R. D. School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK e-mail: s.m.shimeld@reading.ac.uk Tel.: +44-118-9875123 ext. 7084, Fax: +44-118-9310180, GB aut NATIONALLICENCE 700 1- Panopoulou G. D. Max-Planck-Institut für Molekulare Genetik, 14195 Berlin-Dahlem, Germany, DE aut NATIONALLICENCE 700 1- Holland P. W. H. School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK e-mail: s.m.shimeld@reading.ac.uk Tel.: +44-118-9875123 ext. 7084, Fax: +44-118-9310180, GB aut NATIONALLICENCE 700 1- Shimeld S. M. School of Animal and Microbial Sciences, University of Reading, Whiteknights, PO Box 228, Reading RG6 6AJ, UK e-mail: s.m.shimeld@reading.ac.uk Tel.: +44-118-9875123 ext. 7084, Fax: +44-118-9310180, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer