caa a22 4500 475768256 CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s004270050304 doi (NATIONALLICENCE)springer-10.1007/s004270050304 A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster [Elektronische Daten] [M. J. Cann, E. Chung, L. R. Levin] Abstract : We describe the cloning and characterization of a new gene family of adenylyl cyclase related genes in Drosophila. The five adenylyl cyclase-like genes that define this family are clearly distinct from previously known adenylyl cyclases. One member forms a unique locus on chromosome 3 whereas the other four members form a tightly clustered, tandemly repeated array on chromosome 2. The genes on chromosome 2 are transcribed in the male germline in a doublesex dependent manner and are expressed in postmitotic, meiotic, and early differentiating sperm. These genes therefore provide the first evidence for a role for the cAMP signaling pathway in Drosophila spermatogenesis. Expression from this locus is under the control of the always early, cannonball, meiosis arrest, and spermatocyte arrest genes that are required for the G2/M transition of meiosis I during spermatogenesis, implying a mechanism for the coordination of differentiation and proliferation. Evidence is also provided for positive selection at the locus on chromosome 2 which suggests this gene family is actively evolving and may play a novel role in spermatogenesis. Springer-Verlag Berlin Heidelberg, 2000 Key words Drosophila melanogaster nationallicence Adenylyl cyclase nationallicence Spermatogenesis nationallicence Doublesex nationallicence Meiosis nationallicence Cann M. J. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut Chung E. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut Levin L. R. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut https://doi.org/10.1007/s004270050304 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050304 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cann M. J. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut NATIONALLICENCE 700 1- Chung E. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut NATIONALLICENCE 700 1- Levin L. R. Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA E-mail: llevin@mail.med.cornell.edu Tel.: +1-212-7466752, Fax: +1-212-7468835, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer