caa a22 4500 475768280 CHVBK 20180406123612.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s004270050310 doi (NATIONALLICENCE)springer-10.1007/s004270050310 ASW [Elektronische Daten] a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad [Michael O'Neill, Michele Binder, Craig Smith, J. Andrews, Kirsty Reed, Matthijs Smith, Craig Millar, David Lambert, A. Sinclair] Abstract : Vertebrates exhibit a variety of sex determining mechanisms which fall broadly into two classes: environmental or genetic. In birds and mammals sex is determined by a genetic mechanism. In mammals males are the heterogametic sex (XY) with the Y chromosome acting as a dominant determiner of sex due to the action of the testis-determining factor, SRY. In birds females are the heterogametic sex (ZW); however, it is not known whether the W chromosome carries a dominant ovary-determining gene, or whether Z chromosome dosage determines sex. Using an experimental approach, which assumes only that the sex-determining event in birds is accompanied by sex-specific changes in gene expression, we have identified a novel gene, ASW (Avian Sex-specific W-linked). The putative protein for ASW is related to the HIT (histidine triad) family of proteins. ASW shows female-specific expression in genital ridges and maps to the chicken W chromosome. In addition, we show that, with the exception of ratites, ASW is linked to the W chromosome in each of 17 bird species from nine different families of the class Aves. Springer-Verlag Berlin Heidelberg, 2000 Key words Female-specific nationallicence Gene expression nationallicence Avian W-chromosome nationallicence Gonad development nationallicence O'Neill Michael Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut Binder Michele Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut Smith Craig Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut Andrews J. Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut Reed Kirsty Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut Smith Matthijs Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut Millar Craig Department of Ecology. Massey University, Palmerston North, New Zealand, NZ aut Lambert David Department of Ecology. Massey University, Palmerston North, New Zealand, NZ aut Sinclair A. Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut https://doi.org/10.1007/s004270050310 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270050310 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- O'Neill Michael Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut NATIONALLICENCE 700 1- Binder Michele Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut NATIONALLICENCE 700 1- Smith Craig Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut NATIONALLICENCE 700 1- Andrews J. Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut NATIONALLICENCE 700 1- Reed Kirsty Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut NATIONALLICENCE 700 1- Smith Matthijs Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut NATIONALLICENCE 700 1- Millar Craig Department of Ecology. Massey University, Palmerston North, New Zealand, NZ aut NATIONALLICENCE 700 1- Lambert David Department of Ecology. Massey University, Palmerston North, New Zealand, NZ aut NATIONALLICENCE 700 1- Sinclair A. Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia E-mail: sinclair@cryptic.rch.unimelb.edu.a Tel.: +61-3-93456371, Fax: +61-3-93456000, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer