caa a22 4500 475768469 CHVBK 20180406123613.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s004270000094 doi (NATIONALLICENCE)springer-10.1007/s004270000094 Temporal and spatial patterns of cbfal expression during embryonic development in the teleost, Oryzias latipes [Elektronische Daten] [Keiji Inohaya, A. Kudo] Abstract  : Cbfa1, a transcription factor of the runt family, was recently shown to be a key regulator in skeletal development in mammals. In the present study, we identified the cbfa1 gene from the medaka, Oryzias latipes. The amino acid sequence, including the runt domain, is highly conserved with that of mammalian cbfa1. Whole mount in situ hybridization showed that the medaka cbfa1 was expressed prominently in immature osteoblasts and chondrocytes of the developing skeletal structures during embryogenesis. The expression pattern suggests functional and evolutionary implications of the cbfa1 gene in chondrocyte differentiation between teleosts and mammals. Springer-Verlag Berlin Heidelberg, 2000 Key words  cbfa1/Run×2 nationallicence Runt family nationallicence Medaka nationallicence Oryzias latipes nationallicence Skeletal development nationallicence Inohaya Keiji Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan e-mail: akudo@bio.titech.ac.jp Tel.: +81-45-9245718, Fax: +81-45-9245718, JP aut Kudo A. Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan e-mail: akudo@bio.titech.ac.jp Tel.: +81-45-9245718, Fax: +81-45-9245718, JP aut https://doi.org/10.1007/s004270000094 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004270000094 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inohaya Keiji Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan e-mail: akudo@bio.titech.ac.jp Tel.: +81-45-9245718, Fax: +81-45-9245718, JP aut NATIONALLICENCE 700 1- Kudo A. Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan e-mail: akudo@bio.titech.ac.jp Tel.: +81-45-9245718, Fax: +81-45-9245718, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer