caa a22 4500 475770889 CHVBK 20180406123616.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s001250050008 doi (NATIONALLICENCE)springer-10.1007/s001250050008 Both insulin sensitivity and insulin clearance in children and young adults with Type I (insulin-dependent) diabetes vary with growth hormone concentrations and with age [Elektronische Daten] [C. L. Acerini, T. D. Cheetham, J. A. Edge, D. B. Dunger] Aims/hypothesis. We measured insulin clearance rates in children and young adults with Type I (insulin-dependent) diabetes mellitus to establish their relation with insulin sensitivity and with factors such as growth hormone secretion and body mass index.¶Methods. We studied 46 subjects [mean (range) age 14.4 (9.8-24.6) years), body mass index 21.1 (15.8-29.6)Kgm2] using an overnight (1800-0800 hours) variable rate insulin infusion euglycaemic clamp protocol (5 mmol/l). Plasma free insulin concentrations during steady-state euglycaemia were used as an index of insulin sensitivity and insulin clearance determined as a ratio of insulin infusion rate to plasma free insulin.¶Results. During steady-state euglycaemia (0500-0730 hours), insulin sensitivity [mean (SEM) plasma insulin 0.020 (0.002) mU/l] and insulin clearance rates [19.1 (1.8) ml · kg-1· min] varied with age non-linearly and in a reciprocal fashion to each other (cubic regression F = 4.09, p = 0.01; F = 3.55, p = 0.02, respectively). Insulin sensitivity was negatively related to BMI (r = -0.37, p = 0.011) and mean overnight growth hormone concentrations (r = -0.40, p = 0.007). Insulin clearance was only related to growth hormone concentrations (r = -0.37, p = 0.014). These relations were still evident after stepwise multiple regression analysis (potential determinants: C peptide, sex, age, puberty stage, HbA1 c, duration of diabetes): insulin sensitivity r = 0.55, p < 0.001; insulin clearance r = 0.37, p < 0.02.¶Conclusions/interpretation. Insulin clearance rates vary with age in young subjects with Type I diabetes and are highest during mid-adolescence when insulin sensitivity is at its lowest. Both insulin sensitivity and insulin clearance are related to circulating growth hormone concentrations. [Diabetologia (2000) 43: 61-68] Springer-Verlag Berlin Heidelberg, 2000 Keywords Type I diabetes, insulin sensitivity, insulin clearance, growth hormone, age, body mass index, children and adolescents nationallicence Acerini C. L. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut Cheetham T. D. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut Edge J. A. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut Dunger D. B. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut https://doi.org/10.1007/s001250050008 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050008 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Acerini C. L. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut NATIONALLICENCE 700 1- Cheetham T. D. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut NATIONALLICENCE 700 1- Edge J. A. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut NATIONALLICENCE 700 1- Dunger D. B. Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Oxford, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer