caa a22 4500 475770919 CHVBK 20180406123616.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s001250050013 doi (NATIONALLICENCE)springer-10.1007/s001250050013 Effects of diabetic cardiomyopathy on regional electrophysiologic characteristics of rat ventricle [Elektronische Daten] [O. Casis, M. Gallego, M. Iriarte, J. A. Sánchez-Chapula] Abstract : Aims/hypothesis. To identify the possible causes of the lengthening of the action potential duration described in patients affected by diabetes mellitus.¶Methods. We studied the effects of streptozotocin-induced diabetes on the current density of the repolarising potassium currents Ito, IK, Iss and IK1 in enzymatically isolated myocytes from three different regions of rat heart: total right ventricle, subepicardium at the apex of the left ventricle and subendocardium at the base of the left ventricle.¶Results. No changes in IK1 were found due to diabetes, but there was a uniform decrease in Ito (50 %) and Iss (40 %) current densities in the three regions. In contrast, IK diminished unevenly, with the greatest decrease in the subendocardium at the base of the left ventricle (48 %), followed by the subepicardium at the apex of the left ventricle (32 %) and right ventricle (10 %).¶Conclusion/interpretation. These findings suggest the existence of regional differences in ion channel expression associated with diabetes. The decrease of these repolarising currents could account for the lengthening of action potential and the consequent change in the Q-T interval of the ECG observed in diabetic rats. [Diabetologia (2000) 43: 101-109] Springer-Verlag Berlin Heidelberg, 2000 Keywords Patch-clamp, potassium currents, diabetes, action potential, rat nationallicence Casis O. University of the Basque Country, School of Pharmacy, Department of Physiology, Bilbao, Spain, ES aut Gallego M. University of the Basque Country, School of Pharmacy, Department of Physiology, Bilbao, Spain, ES aut Iriarte M. Foundation for Research and Teaching of Cardiovascular Diseases (FIDEC), Bilbao, Spain, ES aut Sánchez-Chapula J. A. University Centre for Biomedical Research, University of Colima, Mexico, MX aut https://doi.org/10.1007/s001250050013 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050013 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Casis O. University of the Basque Country, School of Pharmacy, Department of Physiology, Bilbao, Spain, ES aut NATIONALLICENCE 700 1- Gallego M. University of the Basque Country, School of Pharmacy, Department of Physiology, Bilbao, Spain, ES aut NATIONALLICENCE 700 1- Iriarte M. Foundation for Research and Teaching of Cardiovascular Diseases (FIDEC), Bilbao, Spain, ES aut NATIONALLICENCE 700 1- Sánchez-Chapula J. A. University Centre for Biomedical Research, University of Colima, Mexico, MX aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer