caa a22 4500 47577115X CHVBK 20180406123617.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s001250051379 doi (NATIONALLICENCE)springer-10.1007/s001250051379 A sustained, non-insulin related, hypoglycaemic effect of electroacupuncture in diabetic Psammomys obesus [Elektronische Daten] [M. Y. Shapira, E. Y. Appelbaum, B. Hirshberg, Y. Mizrahi, H. Bar-On, E. Ziv] Aim/hypothesis. Electroacupuncture has been shown to induce a short-term hypoglycaemic effect in streptozotocin diabetic rats. We designed an experiment to investigate the effect of electroacupuncture in Psammomys obesus, a model of insulin resistance and non-insulin-dependent diabetes mellitus.¶Methods. We divided 29 diabetic Psammomys randomly into three groups: abdominal electroacupuncture (real, n = 11), back electroacupuncture (placebo, n = 9) and control (anaesthesia, n = 9). Electroacupuncture was carried out on days 1, 3 and 5 of the experiment. During the first week of the experiment, blood glucose was tested three times on treatment days and once on the following days. Over the next 2 weeks, blood glucose was tested every other day. Animals were weighed at the same time of blood sampling. After 3 weeks, at the end of the experiment, blood was drawn for measurement of insulin, fructosamine, cholesterol and triglycerides.¶Results. At day 5 (end of intervention), blood glucose (as per cent of primary concentrations, means ± SE) was 57 ± 10, 93 ± 13 and 89 ± 11 for the real, placebo and control groups respectively (p = 0.02). At day 8, blood glucose 68 ± 14, 86 ± 16 and 97 ± 9 for the real, placebo and control groups respectively (p = 0.04). At day 22, blood glucose was 79 ± 11, 85 ± 15 and 131 ± 2 for the real, placebo and control groups (p = 0.04). Comparison of the decline in blood glucose, throughout the 3 weeks, between the real and placebo groups by ANOVA was highly significant (p < 0.0001), the difference between the placebo and control groups at the same time was not significant (p > 0.05). Animal weight gain, serum insulin, fructosamine, cholesterol and triglycerides were not significantly different between real and placebo groups.¶Conclusion/interpretation. Electroacupuncture at special abdominal acupoints induces a sustained hypoglycaemic effect in diabetic Psammomys compared with electroacupuncture at non-specific points, without weight loss. No hypoinsulinaemic effect was shown in the real and placebo groups. [Diabetologia (2000) 43: 809-813] Springer-Verlag Berlin Heidelberg, 2000 Keywords Chinese medicine, acupuncture, alternative medicine, diabetes mellitus, Psammomys obesus, insulin resistance nationallicence Shapira M. Y. Division of Internal Medicine, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut Appelbaum E. Y. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut Hirshberg B. Division of Internal Medicine, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut Mizrahi Y. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut Bar-On H. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut Ziv E. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut https://doi.org/10.1007/s001250051379 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051379 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shapira M. Y. Division of Internal Medicine, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Appelbaum E. Y. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Hirshberg B. Division of Internal Medicine, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Mizrahi Y. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Bar-On H. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut NATIONALLICENCE 700 1- Ziv E. Diabetes Research Unit, Hadassah University Hospital, Hebrew University - Hadassah Medical School, Jerusalem, Israel, IL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer