caa a22 4500 475771168 CHVBK 20180406123617.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s001250051367 doi (NATIONALLICENCE)springer-10.1007/s001250051367 Increased fetal leptin in Type I diabetes mellitus pregnancies complicated by chronic hypoxia [Elektronische Daten] [T. K. Hytinantti, H. A. Koistinen, K. Teramo, S. -L. Karonen, V. A. Koivisto, S. Andersson] Aims/hypothesis. The purpose of this study was to examine whether fetal leptin concentration correlates with severity of chronic or subchronic fetal hypoxia as indicated by increased fetal concentrations of erythropoietin in fetuses of mothers with Type I (insulin dependent) diabetes mellitus.¶Methods. We measured leptin and erythropoietin concentrations in cord plasma and amniotic fluid with radioimmunoassay in 25 pregnancies (gestational age 37.2 ± 1.0 weeks). Fetuses with amniotic fluid erythropoietin over 22.5 mU/ml were classified as hypoxic (n = 9) and those with amniotic fluid erythropoietin below 22.5 mU/ml (n = 16) as non-hypoxic.¶Results. The hypoxic fetuses had significantly higher cord leptin concentrations than non-hypoxic fetuses (median 36.8; range, 12.5-135.1 vs median 16.2; range, 3.7-52.2 μg/l), (p = 0.0066). Cord plasma leptin (n = 25) correlated directly with amniotic fluid erythropoietin (r = 0.727, p = 0.0001), with cord plasma erythropoietin (r = 0.644, p = 0.0005) and with the maternal last trimester HbA1C (r = 0.612, p = 0.0019) and negatively with cord artery pO2 (r = -0.440, p = 0.032), and pH (r = -0.414, p = 0.040).¶Conclusion/interpretation. Fetal leptin concentrations increased concomitantly with erythropoietin during chronic or subchronic hypoxia. This phenomenon could indicate a role for leptin in fetal adaptation to hypoxia. [Diabetologia (2000) 43: 709-713] Springer-Verlag Berlin Heidelberg, 2000 Keywords Leptin, erythropoietin, hypoxia, fetus, diabetes mellitus nationallicence Hytinantti T. K. Helsinki City Maternity Hospital, Helsinki University Central Hospital, Helsinki, Finland, FI aut Koistinen H. A. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, FI aut Teramo K. Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland, FI aut Karonen S. -L Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland, FI aut Koivisto V. A. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, FI aut Andersson S. Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland, FI aut https://doi.org/10.1007/s001250051367 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051367 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hytinantti T. K. Helsinki City Maternity Hospital, Helsinki University Central Hospital, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Koistinen H. A. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Teramo K. Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Karonen S. -L Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Koivisto V. A. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Andersson S. Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland, FI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer