caa a22 4500 475771206 CHVBK 20180406123617.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s001250051368 doi (NATIONALLICENCE)springer-10.1007/s001250051368 Effects of size at birth, gestational age and early growth in preterm infants on glucose and insulin concentrations at 9-12 years [Elektronische Daten] [M. S. Fewtrell, C. Doherty, T. J. Cole, M. Stafford, C. N. Hales, A. Lucas] Aims/hypothesis. To test the hypothesis that small size for gestation and poor postnatal growth in preterm infants is associated with higher fasting and post-load plasma glucose and insulin concentrations at 9-12 years of age.¶Methods. Prospective follow-up at 9-12 years of 385 preterm children with birth weight less than 1850 g, who had anthropometry recorded at birth, 18 months and 7 years. Fasting plasma glucose, insulin, proinsulin and 32,33 split proinsulin concentrations and glucose and insulin concentrations 30 min after a standard glucose load were measured.¶Results. Post-load glucose concentrations were negatively related to birth weight, independently of gestation or subsequent growth. Fasting split proinsulin and 30-min insulin concentrations were highest in children who showed the greatest increase in weight centile between birth and current follow-up, regardless of gestation. When weight during childhood was included, birthweight centile was, however, no longer statistically significant: concentrations of fasting, split, proinsulin and 30-min insulin were highest in those children who had shown the greatest increase in weight centile between 18 months of age and current follow-up, with no evidence of a greater effect in those who were smallest at 18 months.¶Conclusion/interpretation. Our findings suggest that fetal growth influences plasma glucose 30 min after a glucose load in preterm children at 9-12 years. In contrast, childhood weight gain is the most important factor influencing insulin concentrations and this effect is the same regardless of early size. [Diabetologia (2000) 43: 714-717] Springer-Verlag Berlin Heidelberg, 2000 Keywords Type II diabetes mellitus, preterm infant, childhood, glucose, insulin, birth weight, growth nationallicence Fewtrell M. S. MRC Human Nutrition Research, Cambridge, UK, GB aut Doherty C. University Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK, GB aut Cole T. J. MRC Human Nutrition Research, Cambridge, UK, GB aut Stafford M. Department of Epidemiology and Public Health, UCL Medical School, London, UK, GB aut Hales C. N. MRC Human Nutrition Research, Cambridge, UK, GB aut Lucas A. MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK, GB aut https://doi.org/10.1007/s001250051368 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051368 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fewtrell M. S. MRC Human Nutrition Research, Cambridge, UK, GB aut NATIONALLICENCE 700 1- Doherty C. University Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK, GB aut NATIONALLICENCE 700 1- Cole T. J. MRC Human Nutrition Research, Cambridge, UK, GB aut NATIONALLICENCE 700 1- Stafford M. Department of Epidemiology and Public Health, UCL Medical School, London, UK, GB aut NATIONALLICENCE 700 1- Hales C. N. MRC Human Nutrition Research, Cambridge, UK, GB aut NATIONALLICENCE 700 1- Lucas A. MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer