caa a22 4500 475771214 CHVBK 20180406123617.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s001250051365 doi (NATIONALLICENCE)springer-10.1007/s001250051365 Sleep apnoea in children with diabetes mellitus: effect of glycaemic control [Elektronische Daten] [M. P. Villa, G. Multari, M. Montesano, J. Pagani, M. Cervoni, F. Midulla, E. Cerone, R. Ronchetti] Aims/hypothesis. Patients with diabetes mellitus commonly have cardiovascular autonomic dysfunction and an abnormal ventilatory pattern during sleep. Few data are available on these changes in childhood diabetes. We investigated whether young diabetic children with or without diabetic neuropathy have ventilatory dysfunction during sleep and if so, whether these autonomic changes are related to the duration of diabetes and glycaemic control.¶Methods. We studied 25 children with insulin-dependent diabetes mellitus (19 boys, mean age 7.72 ± 1.99 years). All patients were insulin-dependent at diagnosis; blood samples for HbA1 c assay were collected on the morning before testing and at 3-month intervals during the preceding year. Patients and control subjects (20 age-matched healthy children, 15 boys) underwent overnight polysomnography.¶Results. More diabetic patients than control subjects had sleep apnoeas (p = 0.006); apnoeas in patients also lasted longer (p = 0.07). Patients with poorly controlled diabetes had more apnoeas than patients with well-controlled diabetes and than healthy control subjects (p < 0.0001). Respiratory events during sleep correlated significantly with glycaemic control (r = 0.360; p = 0.09) and with the duration of diabetes (r = 0.430; p = 0.04).¶Conclusion/interpretation. We conclude that respiratory control is compromised very early in children with diabetes. These anomalies are closely related to the duration of diabetes and to glycaemic control. In young children with diabetes, screening of ventilatory control using recording techniques that are simpler than polysomnography could provide an early indication that an adverse cardiopulmonary reaction has begun. [Diabetologia (2000) 43: 696-702] Springer-Verlag Berlin Heidelberg, 2000 Keywords Sleep apnoea, diabetes, children, autonomic nervous dysfunction, glycaemic control nationallicence Villa M. P. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Multari G. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Montesano M. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Pagani J. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Cervoni M. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Midulla F. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Cerone E. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Ronchetti R. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut https://doi.org/10.1007/s001250051365 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051365 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Villa M. P. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut NATIONALLICENCE 700 1- Multari G. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut NATIONALLICENCE 700 1- Montesano M. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut NATIONALLICENCE 700 1- Pagani J. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut NATIONALLICENCE 700 1- Cervoni M. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut NATIONALLICENCE 700 1- Midulla F. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut NATIONALLICENCE 700 1- Cerone E. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut NATIONALLICENCE 700 1- Ronchetti R. II Paediatric Clinic, University "La Sapienza”, Rome, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer