caa a22 4500 475771273 CHVBK 20180406123617.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s001250051503 doi (NATIONALLICENCE)springer-10.1007/s001250051503 Contribution of visceral obesity to the deterioration of the metabolic risk profile in men with impaired glucose tolerance [Elektronische Daten] [A. Pascot, J. P. Després, I. Lemieux, J. Bergeron, A. Nadeau, D. Prud'homme, A. Tremblay, S. Lemieux] Aims/hypothesis. Impaired glucose tolerance is associated with metabolic alterations which increase cardiovascular disease risk. The contribution of hyperglycaemia to this increased risk is, however, not clear. Abdominal obesity is often observed in subjects with impaired glucose tolerance; our objective was therefore to find the contribution of visceral adipose tissue to the deterioration of the metabolic risk profile noted in subjects with impaired glucose tolerance. Methods. We studied 284 men with a normal glucose tolerance and 66 men with impaired glucose tolerance which was defined as a glycaemia between 7.8 and 11.1 mmol/l 2 h after a 75-g glucose load. Results. Men with impaired glucose tolerance had more visceral adipose tissue and higher concentrations of plasma glucose and insulin in the fasting state and following a 75-g oral glucose load than men with a normal glucose tolerance. They also had higher concentrations of plasma cholesterol, triglycerides, apolipoprotein B and lower concentrations of HDL-cholesterol as well as higher cholesterol:HDL-cholesterol ratios than men with a normal glucose tolerance. The two groups of men were then compared after a statistical adjustment for the amount of visceral adipose tissue. Although men with impaired glucose tolerance still had higher fasting plasma glucose and insulin concentrations after the adjustment for visceral adipose tissue, differences in all the variables of the lipid-lipoprotein profile were eliminated. Conclusion/interpretation. Visceral adipose tissue accumulation is an important factor in the deterioration of the plasma lipid-lipoprotein noted in men with impaired glucose tolerance. [Diabetologia 2000 43: 1126-1135] Springer-Verlag Berlin Heidelberg, 2000 Keywords Impaired glucose tolerance nationallicence visceral obesity nationallicence lipid-lipoprotein nationallicence cardiovascular disease risk nationallicence men nationallicence Pascot A. Lipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut Després J. P. Québec Heart Institute, Hôpital Laval Research Center, Ste-Foy, Québec, Canada, CA aut Lemieux I. Lipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut Bergeron J. Lipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut Nadeau A. Diabetes Research Unit, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut Prud'homme D. Division of Kinesiology, Laval University, Ste-Foy, Québec, Canada, CA aut Tremblay A. Division of Kinesiology, Laval University, Ste-Foy, Québec, Canada, CA aut Lemieux S. Department of Food Science and Nutrition, Laval University, Ste-Foy, Québec, Canada, CA aut https://doi.org/10.1007/s001250051503 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051503 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pascot A. Lipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut NATIONALLICENCE 700 1- Després J. P. Québec Heart Institute, Hôpital Laval Research Center, Ste-Foy, Québec, Canada, CA aut NATIONALLICENCE 700 1- Lemieux I. Lipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut NATIONALLICENCE 700 1- Bergeron J. Lipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut NATIONALLICENCE 700 1- Nadeau A. Diabetes Research Unit, CHUL Research Center, Ste-Foy, Québec, Canada, CA aut NATIONALLICENCE 700 1- Prud'homme D. Division of Kinesiology, Laval University, Ste-Foy, Québec, Canada, CA aut NATIONALLICENCE 700 1- Tremblay A. Division of Kinesiology, Laval University, Ste-Foy, Québec, Canada, CA aut NATIONALLICENCE 700 1- Lemieux S. Department of Food Science and Nutrition, Laval University, Ste-Foy, Québec, Canada, CA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer