caa a22 4500 475771354 CHVBK 20180406123618.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s001250051510 doi (NATIONALLICENCE)springer-10.1007/s001250051510 Reduced capillary hydraulic conductivity in skeletal muscle and skin in Type I diabetes: a possible cause for reduced transcapillary fluid absorption during hypovolaemia [Elektronische Daten] [H. Olsen, T. Länne] Aims/hypothesis. Patients with Type I (insulin-dependent) diabetes mellitus have a reduced transcapillary fluid absorption from skeletal muscle and skin and thus defective plasma volume regulation during hypovolaemia. Our aim was to find whether a defective capillary filtration coefficient or impaired transcapillary driving force are aetiologic factors for this reduction. Methods. We investigated 11 diabetic patients (diabetes duration 6.9 ± 1.1 years, age 26 ± 1 years), without complications and 12 control subjects (26 ± 1 years). Their capillary filtration coefficient was measured in the upper arm using a volumetric technique at rest and during lower body negative pressure (LBNP). We calculated the driving force for transcapillary fluid transfer. Results. The increase in heart rate and the decrease in systolic blood pressure during lower body negative pressure were similar in diabetic and control subjects. The resting capillary filtration coefficient was decreased in the diabetic subjects, 0.033 ± 0.003 vs 0.051 ± 0.007 ml · 100 ml-1· min-1· mmHg-1 (p < 0.05). During lower body negative pressure, the capillary filtration coefficient increased 35 % in both groups compared with resting capillary filtration coefficient and was still decreased in diabetes; 0.046 ± 0.004 compared with 0.069 ± 0.006 ml · 100ml-1· min-1· mmHg-1 (p < 0.01). The established driving force during lower body negative pressure was 1.37 ± 0.11 vs 1.30 ± 0.15 mmHg (NS) in diabetic and control subjects, respectively. Conclusions/interpretation. Our study indicates that a reduced capillary filtration coefficient rather than defective regulation of transcapillary driving force, is the reason for the reduced transcapillary fluid absorption during hypovolaemic circulatory stress found in Type I diabetic patients. [Diabetologia (2000) 43: 1178-1184] Springer-Verlag Berlin Heidelberg, 2000 Keywords LBNP nationallicence capillary filtration coefficient nationallicence sympathetic activation nationallicence diabetes mellitus nationallicence muscle nationallicence Olsen H. Department of Endocrinology, Lund University, Malmö University Hospital, Malmö, Sweden, SE aut Länne T. Department of Vascular and Renal Diseases, Lund University, Malmö University Hospital, Malmö, Sweden, SE aut https://doi.org/10.1007/s001250051510 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051510 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Olsen H. Department of Endocrinology, Lund University, Malmö University Hospital, Malmö, Sweden, SE aut NATIONALLICENCE 700 1- Länne T. Department of Vascular and Renal Diseases, Lund University, Malmö University Hospital, Malmö, Sweden, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer