caa a22 4500 475771362 CHVBK 20180406123618.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s001250051498 doi (NATIONALLICENCE)springer-10.1007/s001250051498 Scharfmann R. INSERM U457 Hospital R. Debré, Paris, XX aut Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme [Elektronische Daten] [R. Scharfmann] During the last few years, progress has been made in the control of pancreatic development. Many transcription factors have been described in the pancreas and a genetic approach has been used to define their role in pancreatic development. Pancreatic development depends on mesodermic signals, with the initial steps controlled by signals from the notochord that is in close contact with the dorsal endoderm of the gut fated to become pancreas. Later signals from the mesenchyme that surrounds the embryonic pancreatic epithelium regulate the proliferation of immature pancreatic epithelial cells and their differentiation into endocrine or exocrine tissue. This review discusses recent data on the role the signals from the mesenchyme have in the development of the pancreas in rodents and humans. [Diabetologia (2000) 43: 1083-1092] Springer-Verlag Berlin Heidelberg, 2000 Keywords Pancreas nationallicence development nationallicence epithelium nationallicence mesenchyme nationallicence proliferation nationallicence differentiation nationallicence https://doi.org/10.1007/s001250051498 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051498 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Scharfmann R. INSERM U457 Hospital R. Debré, Paris, XX aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer