caa a22 4500 475771559 CHVBK 20180406123618.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s001250051470 doi (NATIONALLICENCE)springer-10.1007/s001250051470 Role of insulin-like growth factor (IGF)-1 in the modulation of renal haemodynamics in Type I diabetic patients [Elektronische Daten] [S. Bacci, S. De Cosmo, M. Garruba, G. Placentino, A. Liuzzi, F. Barbano, A. Di Giorgio, V. Trischitta, G. C. Viberti] Aims/hypothesis. We investigated in normotensive Type I (insulin-dependent) diabetic patients with normoalbuminuria the role of growth hormone-induced IGF-1 in the modulation of renal haemodynamics.¶Methods. We measured glomerular filtration (GFR) and renal plasma flow (RPF) at baseline and at 24 h after injection of different doses of growth hormone (0.1, 0.2, 0.4 U · kg-1· body weight-1) in six patients with normal GFR under a euglycaemic clamp. We also examined a 24-h profile of plasma growth hormone and IGF-1 during usual insulin therapy in two other groups each with seven patients with a lower (from 93 to 114 ml · min-1· (1.73 m2)-1) and higher (from 121 to 146 ml · min-1· (1.73 m2)-1) GFR.¶Results. Plasma growth hormone concentrations peaked 2 h after its injection and plasma concentrations of IGF-1 peaked about 24 h after the growth hormone injection. There was a significant increase in GFR and RPF 24 h after the highest dose of the growth hormone injection (corresponding to the highest IGF-1 concentration), from baseline values of 115 ± 24 and 536 ± 141 ml · min-1· (1.73 m2)-1 to 160 ± 33 and 657 ± 137 ml · min-1· (1.73 m2)-1, respectively (p < 0.01 for GFR and p < 0.05 for RPF). No differences were observed in the 24-h profile of growth hormone and IGF-1 plasma concentrations between the two groups; growth hormone and IGF-1 concentrations were lower than those obtained after the injection of 0.4 U · kg-1· body weight-1 of growth hormone.¶Conclusion/interpretation. These results show that pharmacological growth hormone-induced IGF-1 concentrations are required to modify renal haemodynamics in Type I diabetic patients and suggest that, under the "physiological” conditions of diabetes, IGF-1 has no role as a mediator of glomerular hyperfiltration. [Diabetologia (2000) 43: 922-926] Springer-Verlag Berlin Heidelberg, 2000 Keywords Glomerular filtration rate, renal plasma flow, growth hormone nationallicence Bacci S. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut De Cosmo S. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut Garruba M. Division and Research Unit of Clinical Chemistry Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut Placentino G. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut Liuzzi A. Division of Endocrinology, Italian Institute of Growth, Scientific Institute "San Giuseppe”, Piancavallo, Italy, IT aut Barbano F. Department of Nuclear Medicine, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut Di Giorgio A. Division and Research Unit of Clinical Chemistry Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut Trischitta V. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut Viberti G. C. Unit for Metabolic Medicine, Department of Endocrinology, Diabetes and Internal Medicine, GKT School of Medicine, Guy's Hospital, King's College London, London, UK, GB aut https://doi.org/10.1007/s001250051470 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051470 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bacci S. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut NATIONALLICENCE 700 1- De Cosmo S. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut NATIONALLICENCE 700 1- Garruba M. Division and Research Unit of Clinical Chemistry Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut NATIONALLICENCE 700 1- Placentino G. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut NATIONALLICENCE 700 1- Liuzzi A. Division of Endocrinology, Italian Institute of Growth, Scientific Institute "San Giuseppe”, Piancavallo, Italy, IT aut NATIONALLICENCE 700 1- Barbano F. Department of Nuclear Medicine, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut NATIONALLICENCE 700 1- Di Giorgio A. Division and Research Unit of Clinical Chemistry Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut NATIONALLICENCE 700 1- Trischitta V. Division and Research Unit of Endocrinology, Scientific Institute "Casa Sollievo della Sofferenza”, San Giovanni Rotondo, Italy, IT aut NATIONALLICENCE 700 1- Viberti G. C. Unit for Metabolic Medicine, Department of Endocrinology, Diabetes and Internal Medicine, GKT School of Medicine, Guy's Hospital, King's College London, London, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer