caa a22 4500 475771729 CHVBK 20180406123619.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s001250051561 doi (NATIONALLICENCE)springer-10.1007/s001250051561 Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test [Elektronische Daten] [M. Albareda, J. Rodríguez-Espinosa, M. Murugo, A. de Leiva, R. Corcoy] Aims/hypothesis. We aimed to find if the relation between insulin sensitivity and beta-cell function assessed from fasting and OGTT measurements has a physiological shape (hyperbolic with the reference methods). Methods. Healthy women without diabetic first-degree relatives underwent a 75 g OGTT with plasma glucose and insulin (n = 35) concentrations being measured at 0, 30, 60 and 120 min. Beta-cell function and insulin sensitivity were estimated using previously described indices from fasting (1 for beta-cell function, 6 for insulin sensitivity) and OGTT measurements (3 for beta-cell function and 5 for insulin sensitivity). A hyperbolic relation was tested for the 21 beta-cell function-insulin sensitivity pairs using a non-lineal regression method. Results. The assessment of beta-cell function from OGTT was impossible in seven women and one had outlier indices. For the remaining 27 women, only 8 combinations adjusted to a hyperbolic relation. The best adjustment was achieved using the fasting glucose to insulin ratio as the estimation of insulin sensitivity and the homeostasis model assessment (HOMA) index (single fasting sample) as the estimation of beta-cell function (r 2 0.802, k 869.71, p < 0.001). Conclusion/interpretation. In this group of healthy women, the estimation of insulin sensitivity and beta-cell function by most methods using OGTT-derived glucose and insulin measurements did not adjust to a hyperbolic relation but all fasting indices combinations did. Beta-cell function estimated with the HOMA index and insulin sensitivity with fasting glucose to insulin ratio had the best adjustment. [Diabetologia (2000) 43: 1507-1511] Springer-Verlag Berlin Heidelberg, 2000 Keywords Insulin sensitivity nationallicence OGTT nationallicence Beta-cell function nationallicence insulin secretion nationallicence Albareda M. Department of Endocrinology and Nutrition, Hospital of Sant Pau, Barcelona, Spain, ES aut Rodríguez-Espinosa J. Department of Clinical Biochemistry, Hospital of Sant Pau, Barcelona, Spain, ES aut Murugo M. Department of Clinical Biochemistry, Hospital of Sant Pau, Barcelona, Spain, ES aut de Leiva A. Department of Endocrinology and Nutrition, Hospital of Sant Pau, Barcelona, Spain, ES aut Corcoy R. Department of Endocrinology and Nutrition, Hospital of Sant Pau, Barcelona, Spain, ES aut https://doi.org/10.1007/s001250051561 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051561 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Albareda M. Department of Endocrinology and Nutrition, Hospital of Sant Pau, Barcelona, Spain, ES aut NATIONALLICENCE 700 1- Rodríguez-Espinosa J. Department of Clinical Biochemistry, Hospital of Sant Pau, Barcelona, Spain, ES aut NATIONALLICENCE 700 1- Murugo M. Department of Clinical Biochemistry, Hospital of Sant Pau, Barcelona, Spain, ES aut NATIONALLICENCE 700 1- de Leiva A. Department of Endocrinology and Nutrition, Hospital of Sant Pau, Barcelona, Spain, ES aut NATIONALLICENCE 700 1- Corcoy R. Department of Endocrinology and Nutrition, Hospital of Sant Pau, Barcelona, Spain, ES aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer