caa a22 4500 475771885 CHVBK 20180406123619.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s001250050046 doi (NATIONALLICENCE)springer-10.1007/s001250050046 Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins [Elektronische Daten] [M. Lehtovirta, J. Kaprio, C. Forsblom, J. Eriksson, J. Tuomilehto, L. Groop] Aims/hypothesis. To estimate the heritability of insulin sensitivity and insulin secretion, both of which are considered to contribute to the development of Type II (non-insulin-dependent) diabetes mellitus.¶Methods. Intraclass correlation coefficients and heritability estimates for insulin sensitivity (euglycaemic clamp) as well as first-phase and late-phase insulin secretion (intravenous glucose tolerance test) were calculated in 21 monozygotic and 20 dizygotic twin pairs of the same sex between 54 and 72 years of age.¶Results. Intrapair correlations for all traits were consistently higher in monozygotic than in dizygotic pairs. Insulin secretion correlated significantly only between monozygotic (first-phase r = 0.55; p = 0.003 and late-phase r = 0.66; p < 0.001) twins giving heritability estimates of 0.55 and 0.58, respectively. Insulin-stimulated glucose uptake showed a more modest correlation between monozygotic twins (r = 0.46; p = 0.015). The heritability estimate was 0.37. The heritability estimate for waist-to-hip ratio was 0.76 in female and 0.70 in male twins.¶Conclusion/interpretation. Genetic variability seems to contribute to the variance of insulin sensitivity as well as of insulin secretion. In the current study, genetic variance accounted almost 60 % for the variance in glucose-stimulated insulin secretion and almost 40 % for the variance in insulin-stimulated glucose uptake. Our data is also compatible with findings in monogenic forms of diabetes in which genetic defects in insulin secretion play a predominant part in the pathogenesis of hyperglycaemia. [Diabetologia (2000) 43: 285-293] Springer-Verlag Berlin Heidelberg, 2000 Keywords Twins, monozygotic, dizygotic, heritability, insulin, insulin resistance nationallicence Lehtovirta M. Department of Medicine, University of Helsinki, Helsinki, Finland, FI aut Kaprio J. Department of Public Health, University of Helsinki, Helsinki, Finland, FI aut Forsblom C. Department of Medicine, University of Helsinki, Helsinki, Finland, FI aut Eriksson J. National Public Health Institute, Helsinki, Finland, FI aut Tuomilehto J. National Public Health Institute, Helsinki, Finland, FI aut Groop L. Department of Endocrinology, University of Lund, Malmö, Sweden, SE aut https://doi.org/10.1007/s001250050046 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050046 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lehtovirta M. Department of Medicine, University of Helsinki, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Kaprio J. Department of Public Health, University of Helsinki, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Forsblom C. Department of Medicine, University of Helsinki, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Eriksson J. National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Tuomilehto J. National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Groop L. Department of Endocrinology, University of Lund, Malmö, Sweden, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer