caa a22 4500 475771958 CHVBK 20180406123619.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s001250050053 doi (NATIONALLICENCE)springer-10.1007/s001250050053 Different risk factors of microangiopathy in patients with Type I diabetes mellitus of short versus long duration. The EURODIAB IDDM Complications Study [Elektronische Daten] [B. Karamanos, M. Porta, M. Songini, Z. Metelko, Z. Kerenyi, G. Tamas, R. Rottiers, L. K. Stevens, J. H. Fuller] Aims/hypothesis. To identify factors associated with early development of and late protection from microvascular complications in subjects with Type I (insulin-dependent) diabetes mellitus.¶Methods. The frequency of microvascular complications and their relation to risk factors were studied in 300 Type I diabetic subjects with short duration of disease ( ≤ 5 years) compared with 1062 subjects with long duration ( ≥ 14 years). Microvascular disease was defined as the presence of either retinopathy (assessed from centrally-graded retinal photographs) or urinary albumin excretion rate of more than 20 μg/min.¶Resu1ts. The prevalence of microvascular disease was 25 % in the short duration group. In the long duration group 18 % had no evidence of microvascular complications. In the short duration group factors associated with early development of complications were cigarette smoking and a family history of hypertension. Subjects free of microvascular complications in spite of long duration of diabetes had better glycaemic control, lower blood pressure, better lipid profile and lower von Willebrand factor levels.¶Conclusion/interpretation. At the early stages of Type I diabetes, cigarette smoking and genetic susceptibility to hypertension are important risk factors for microvascular complications. At a later stage, additional risk factors are poorer glycaemic control, higher blood pressure, and an unfavourable lipid profile possibly associated with endothelial dysfunction. Many of these factors are amenable to long-term intervention which should be started as soon as possible in the course of the disease. [Diabetologia (2000) 43: 348-355] Springer-Verlag Berlin Heidelberg, 2000 Keywords Microvascular complications, retinopathy, nephropathy, hypertension, lipids, lipoproteins, smoking, endothelial dysfunction, von Willebrand factor nationallicence Karamanos B. Diabetes Centre, Hippokration Hospital, Athens, Greece, GR aut Porta M. Department of Internal Medicine, University of Turin, Turin, Italy, IT aut Songini M. Department of Internal Medicine, San Michele Hospital, Cagliari, Italy, IT aut Metelko Z. Vuk Vrhovac Institute for Diabetes, Zagreb, Croatia, HR aut Kerenyi Z. Szent Imre Teaching Hospital, Budapest, Hungary, HU aut Tamas G. First Department of Medicine, Semmelweis University, Budapest, Hungary, HU aut Rottiers R. Department of Endocrinology, University Hospital, Gent, Belgium, BE aut Stevens L. K. EURODIAB, Department of Epidemiology and Public Health, UCL, London, UK, GB aut Fuller J. H. EURODIAB, Department of Epidemiology and Public Health, UCL, London, UK, GB aut https://doi.org/10.1007/s001250050053 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050053 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karamanos B. Diabetes Centre, Hippokration Hospital, Athens, Greece, GR aut NATIONALLICENCE 700 1- Porta M. Department of Internal Medicine, University of Turin, Turin, Italy, IT aut NATIONALLICENCE 700 1- Songini M. Department of Internal Medicine, San Michele Hospital, Cagliari, Italy, IT aut NATIONALLICENCE 700 1- Metelko Z. Vuk Vrhovac Institute for Diabetes, Zagreb, Croatia, HR aut NATIONALLICENCE 700 1- Kerenyi Z. Szent Imre Teaching Hospital, Budapest, Hungary, HU aut NATIONALLICENCE 700 1- Tamas G. First Department of Medicine, Semmelweis University, Budapest, Hungary, HU aut NATIONALLICENCE 700 1- Rottiers R. Department of Endocrinology, University Hospital, Gent, Belgium, BE aut NATIONALLICENCE 700 1- Stevens L. K. EURODIAB, Department of Epidemiology and Public Health, UCL, London, UK, GB aut NATIONALLICENCE 700 1- Fuller J. H. EURODIAB, Department of Epidemiology and Public Health, UCL, London, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer