caa a22 4500 475772156 CHVBK 20180406123620.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s001250051518 doi (NATIONALLICENCE)springer-10.1007/s001250051518 Neonatal Type I diabetes associated with maternal echovirus 6 infection: a case report [Elektronische Daten] [T. Otonkoski, M. Roivainen, O. Vaarala, B. Dinesen, J. A. Leipälä, T. Hovi, M. Knip] Aims/hypothesis. Neonatal diabetes mellitus is rare, and it has not been associated with beta-cell autoimmunity. Enteroviral infections during pregnancy have been implicated as a risk factor for the later development of Type I (insulin-dependent) diabetes mellitus. We now report of a baby girl who was born severely growth-retarded with neonatal insulin-deficient diabetes, and look for evidence of intrauterine enteroviral infections and beta-cell targeted autoimmunity.¶Methods. Diabetes-associated autoimmunity was studied by measurement of several types of islet cell reactive autoantibodies. The infant's T-cell responses to insulin and enterovirus antigens were recorded and enterovirus antibodies were measured both from the mother and the child.¶Results. Several types of diabetes-associated autoantibodies were detected postnatally, including insulin autoantibodies, conventional islet cell autoantibodies and glutamic acid decarboxylase antibodies, whereas no autoantibodies were observed in the mother. The infant's T-cells showed reactivity to insulin and purified enterovirus particles. Based on serological studies, the pathogenetic process could have been triggered by an echovirus 6 infection during pregnancy. The patient's diabetes has been permanent, although there were signs of endogenous insulin production for several months. Exocrine pancreatic insufficiency was diagnosed at the age of 1 year.¶Conclusion/interpretation. These observations suggests that enteroviral infections may induce beta-cell autoimmunity even in utero. [Diabetologia (2000) 43: 1235-1238] Springer-Verlag Berlin Heidelberg, 2000 Keywords Neonatal diabetes mellitus, autoantibodies, enteroviruses, fetal growth retardation nationallicence Otonkoski T. Hospital for Children and Adolescents and Haartman Institute, Transplantation Laboratory, University of Helsinki, Helsinki, Finland, FI aut Roivainen M. National Public Health Institute, Helsinki, Finland, FI aut Vaarala O. National Public Health Institute, Helsinki, Finland, FI aut Dinesen B. Steno Diabetes Center, Gentofte, Denmark, DK aut Leipälä J. A. Hospital for Children and Adolescents and Haartman Institute, Transplantation Laboratory, University of Helsinki, Helsinki, Finland, FI aut Hovi T. National Public Health Institute, Helsinki, Finland, FI aut Knip M. Medical School, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland, FI aut https://doi.org/10.1007/s001250051518 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051518 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Otonkoski T. Hospital for Children and Adolescents and Haartman Institute, Transplantation Laboratory, University of Helsinki, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Roivainen M. National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Vaarala O. National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Dinesen B. Steno Diabetes Center, Gentofte, Denmark, DK aut NATIONALLICENCE 700 1- Leipälä J. A. Hospital for Children and Adolescents and Haartman Institute, Transplantation Laboratory, University of Helsinki, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Hovi T. National Public Health Institute, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Knip M. Medical School, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland, FI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer