caa a22 4500 475772350 CHVBK 20180406123621.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s001250051332 doi (NATIONALLICENCE)springer-10.1007/s001250051332 Response of Charcot's arthropathy to contact casting: assessment by quantitative techniques [Elektronische Daten] [M. McGill, L. Molyneaux, T. Bolton, K. Ioannou, R. Uren, D. K. Yue] Aims/hypothesis. This study used two different methods of quantitative bone scanning to study the relation between activity of Charcot's arthropathy and clinical variables over 12 months.¶Methods. Skin temperature of affected and unaffected feet was measured at baseline and every 3 months for 12 months in 17 subjects. Eight subjects underwent a three-phase quantitative bone scan at baseline and 3 monthly for 12 months. Bone isotope uptake in a standard rectangular area over the foot and tibia was analysed by the bilateral scan method (the ratio of isotope uptake of affected and unaffected feet) and the unilateral scan method (the ratio of isotope uptake of affected foot and ipsilateral tibia). The affected foot was placed in a contact cast for an average of 8 months.¶Results. At presentation the affected foot was hotter than the unaffected foot but the temperature became progressively cooler over 12 months. Median isotope uptake in the affected foot was 2.1 % of the injected dose (interquartile range, IQR 1.9-3.0). In both scanning methods the ratio of uptake decreased after casting but at 12 months the affected foot still had more isotope uptake. There was a strong correlation between temperature difference and the ratio of uptake in the bilateral scan method (r = 0.90; p < 0.0001) but when using the unilateral scan method this relation was not significant (r = 0.1; p = 0.6). A strong relation existed between perfusion of the affected foot in the dynamic phase and isotope uptake in the delayed phase of the scans (r = 0.92; p < 0.0001).¶Conclusion/interpretation. Bone activity and skin temperature of Charcot's arthropathy can be measured quantitatively and both improve over 12 months with contact casting. There is a strong relation between perfusion and disease activity in this condition. [Diabetologia (2000) 43:481-484] Springer-Verlag Berlin Heidelberg, 2000 Keywords Complications, neuropathy, foot, radionuclide scan, podiatry nationallicence McGill M. Department of Medicine, University of Sydney, Sydney, Australia, AU aut Molyneaux L. Diabetes Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, AU aut Bolton T. Diabetes Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, AU aut Ioannou K. Advanced Nuclear Medicine Services, University of Sydney, Sydney, Australia, AU aut Uren R. Advanced Nuclear Medicine Services, University of Sydney, Sydney, Australia, AU aut Yue D. K. Department of Medicine, University of Sydney, Sydney, Australia, AU aut https://doi.org/10.1007/s001250051332 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051332 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McGill M. Department of Medicine, University of Sydney, Sydney, Australia, AU aut NATIONALLICENCE 700 1- Molyneaux L. Diabetes Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, AU aut NATIONALLICENCE 700 1- Bolton T. Diabetes Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, AU aut NATIONALLICENCE 700 1- Ioannou K. Advanced Nuclear Medicine Services, University of Sydney, Sydney, Australia, AU aut NATIONALLICENCE 700 1- Uren R. Advanced Nuclear Medicine Services, University of Sydney, Sydney, Australia, AU aut NATIONALLICENCE 700 1- Yue D. K. Department of Medicine, University of Sydney, Sydney, Australia, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer