caa a22 4500 47577244X CHVBK 20180406123621.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s001250051486 doi (NATIONALLICENCE)springer-10.1007/s001250051486 Usefulness of waveform analysis of popliteal artery in Type II diabetic patients using gated magnetic resonance 2D-cine-PC imaging and 31P spectroscopy [Elektronische Daten] [E. Suzuki, A. Kashiwagi, Y. Nishio, H. Kojima, H. Maegawa, M. Haneda, H. Yasuda, S. Morikawa, T. Inubushi, R. Kikkawa] Abstract : Aims/hypothesis. We studied 76 patients with Type II (non-insulin-dependent) diabetes mellitus and 16 age-matched non-diabetic subjects (control group) to clarify qualitative and quantitative abnormalities of waveform and flow volume of the popliteal artery. Methods. The 76 diabetic patients comprised 16 patients with occlusive arterial disease in the lower extremities [arteriosclerosis obliterans (ASO) group] and 60 patients free from this disease (non-ASO group). We flow analysed the popliteal artery and measured the phosphocreatine to inorganic phosphate ratio of resting plantar muscles to identify risk factors for foot lesions using gated magnetic resonance two-dimensional cine-mode phase-contrast imaging and 31P spectroscopy. Results. The control and non-ASO groups had a triphasic waveform with systolic, early and late diastolic components. All ASO patients had an abnormal monophasic waveform and a lower ankle brachial index than that of the control and non-ASO groups. To clarify the mechanism of reduced flow volume of lower extremities, we assigned the 60 patients of the non-ASO group to the three subgroups based on their levels of total flow volume of the popliteal artery. The lowest group showed an abnormal triphasic waveform with lower amplitudes of systolic and late diastolic components and flow velocities in foot arteries than those of the highest group although ABI was similar. From stepwise multiple regression analysis, late diastolic flow volume was identified as an independent determinant for the phosphocreatine to inorganic phosphate ratio (r 2 = 0.484, p < 0.001). Conclusion/interpretation. Waveform analysis of popliteal artery provides a powerful tool for identifying impaired peripheral circulation caused by either occlusive arterial disease or increased arterial resistance in diabetic patients. [Diabetologia (2000) 43: 1031-1038] Springer-Verlag Berlin Heidelberg, 2000 Keywords Magnetic resonance nationallicence popliteal artery nationallicence waveform nationallicence flow volume nationallicence occlusive arterial disease nationallicence arterial resistance nationallicence plantar muscle nationallicence high energy phosphate content nationallicence Suzuki E. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Kashiwagi A. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Nishio Y. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Kojima H. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Maegawa H. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Haneda M. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Yasuda H. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Morikawa S. Molecular Neurobiology Research Centre, Shiga University of Medical Science, Shiga, Japan, JP aut Inubushi T. Molecular Neurobiology Research Centre, Shiga University of Medical Science, Shiga, Japan, JP aut Kikkawa R. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut https://doi.org/10.1007/s001250051486 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051486 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki E. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Kashiwagi A. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Nishio Y. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Kojima H. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Maegawa H. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Haneda M. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Yasuda H. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Morikawa S. Molecular Neurobiology Research Centre, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Inubushi T. Molecular Neurobiology Research Centre, Shiga University of Medical Science, Shiga, Japan, JP aut NATIONALLICENCE 700 1- Kikkawa R. Third Department of Medicine, Shiga University of Medical Science, Shiga, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer