caa a22 4500 475772679 CHVBK 20180406123622.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s001250051356 doi (NATIONALLICENCE)springer-10.1007/s001250051356 Variables of the insulin resistance syndrome are associated with reduced arterial distensibility in healthy non-diabetic middle-aged women [Elektronische Daten] [N. M. van Popele, I. C. D. Westendorp, M. L. Bots, R. S. Reneman, A. P. G. Hoeks, A. Hofman, D. E. Grobbee, J. C. M. Witteman] Aims/hypothesis. The insulin resistance syndrome is related to arterial stiffness in diabetic subjects. Whether the insulin resistance syndrome is also related to arterial stiffness in non-diabetic subjects is less clear. We studied the association between variables of the insulin resistance syndrome in relation to arterial distensibility in healthy middle-aged non-diabetic women. Methods. This study was done in 180 non-diabetic women, aged 43-55, selected from the general population. Arterial distensibility was assessed in the carotid artery. The associations were evaluated using linear regression analyses. Results. Strong associations were found between arterial distensibility and the variables of the insulin resistance syndrome: body mass index, waist-to-hip ratio, high-density-lipoprotein-cholesterol, triglycerides, glucose, insulin, apolipoprotein A1, plasminogen activator inhibitor-1-antigen and tissue-type plasminogen activator-antigen. After additional adjustment for mean arterial pressure, common carotid arterial distensibility remained associated with body mass index: β-coefficient (95 % confidence interval) per kg/m2: -0.24 (-0.42; -0.06); waist-to-hip ratio: -26.62 (-40.59; -12.65) per m/m; triglycerides: -1.42(-2.77; -0.08) per mmol/l; plasminogen activator inhibitor-1-antigen: -0.01 (-0.02; -0.00) per ng/ml and borderline significant associated with high-density-lipoprotein-cholesterol: 1.93 (-0.01; 3.87; p = 0.07) per mmol/l. Clustering of variables of the insulin resistance syndrome was strongly related to decreased arterial distensibility which remained after adjustment for mean arterial pressure. No association was found between arterial distensibility and variables that are not part of the insulin resistance syndrome: total cholesterol, LDL-cholesterol and apolipoprotein B. Conclusion/interpretation. The results of this study show that variables of the insulin resistance syndrome are associated with decreased arterial distensibility of the common carotid artery in healthy non-diabetic subjects. [Diabetologia (2000) 43: 665-672] Springer-Verlag Berlin Heidelberg, 2000 Keywords Insulin resistance nationallicence arterial stiffness nationallicence healthy subjects nationallicence women nationallicence population nationallicence van Popele N. M. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut Westendorp I. C. D. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut Bots M. L. Julius Centre for Patient Oriented Research, University Medical Centre Utrecht, Utrecht, The Netherlands, NL aut Reneman R. S. Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands, NL aut Hoeks A. P. G. Department of Biophysics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands, NL aut Hofman A. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut Grobbee D. E. Julius Centre for Patient Oriented Research, University Medical Centre Utrecht, Utrecht, The Netherlands, NL aut Witteman J. C. M. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut https://doi.org/10.1007/s001250051356 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051356 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Popele N. M. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Westendorp I. C. D. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Bots M. L. Julius Centre for Patient Oriented Research, University Medical Centre Utrecht, Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Reneman R. S. Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands, NL aut NATIONALLICENCE 700 1- Hoeks A. P. G. Department of Biophysics, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands, NL aut NATIONALLICENCE 700 1- Hofman A. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Grobbee D. E. Julius Centre for Patient Oriented Research, University Medical Centre Utrecht, Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Witteman J. C. M. Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer