caa a22 4500 475772717 CHVBK 20180406123622.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s001250051344 doi (NATIONALLICENCE)springer-10.1007/s001250051344 Glucose tolerance and other determinants of cardiovascular autonomic function: the Hoorn Study [Elektronische Daten] [J. Gerritsen, J. M. Dekker, B. J. TenVoorde, F. W. Bertelsmann, P. J. Kostense, C. D. A. Stehouwer, R. J. Heine, G. Nijpels, R. M. Heethaar, L. M. Bouter] Aims/hypothesis. Currently, three categories of measures are used to assess cardiovascular autonomic dysfunction: measures of the Ewing-test, measures of heart-rate variability, and measures of baroreflex sensitivity. We studied the determinants of these measures obtained from cardiovascular autonomic function tests in the Hoorn Study. Methods. The study group (n = 631) consisted of a glucose-tolerance-stratified sample from a 50- to 75-year-old group of people. Cardiac cycle duration (RR interval) and continuous finger arterial pressure were measured under three conditions: during (a) spontaneous breathing, (b) six deep breaths over one minute, and (c) an active change in position from lying to standing. From these readings, ten measures of autonomic function were assessed (three Ewing, six heart-rate variability and one baroreflex sensitivity). As possible determinants we considered age, sex, glucose tolerance, cardiovascular disease, use of anti-hypertensive drugs, anthropometric factors, metabolic factors and lifestyle factors. Results. Multivariate analysis showed that eight of ten cardiovascular autonomic function measures were most strongly associated with glucose tolerance. Furthermore, measures were moderately associated with age, sex, waist-to-hip ratio, use of anti-hypertensive drugs, and insulin. The measures were weakly associated with coronary artery disease but not with lipids. The strongest determinants seemed to differ between subjects with and without diabetes: in the non-diabetic subjects the most strongly associated were age and use of anti-hypertensive drugs and in subjects with diabetes, insulin. No consistent differences in association between the three categories of measures were observed. Conclusion/interpretation. The strongest determinants of autonomic function were age, presence of diabetes and use of anti-hypertensive drugs. [Diabetologia (2000) 43: 561-570] Springer-Verlag Berlin Heidelberg, 2000 Keywords Aging nationallicence baroreflex nationallicence Type II diabetes mellitus nationallicence cardiovascular disease nationallicence glucose intolerance nationallicence heart-rate variability nationallicence hypertension nationallicence lifestyle nationallicence autonomic nervous system nationallicence obesity nationallicence Gerritsen J. Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Dekker J. M. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut TenVoorde B. J. Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Bertelsmann F. W. Department of Neurology, Hospital Amstelveen, Amstelveen, The Netherlands, NL aut Kostense P. J. Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Stehouwer C. D. A. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Heine R. J. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Nijpels G. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Heethaar R. M. Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Bouter L. M. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut https://doi.org/10.1007/s001250051344 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051344 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gerritsen J. Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Dekker J. M. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- TenVoorde B. J. Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Bertelsmann F. W. Department of Neurology, Hospital Amstelveen, Amstelveen, The Netherlands, NL aut NATIONALLICENCE 700 1- Kostense P. J. Department of Clinical Epidemiology and Biostatistics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Stehouwer C. D. A. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Heine R. J. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Nijpels G. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Heethaar R. M. Department of Clinical Physics and Informatics, Vrije Universiteit, Amsterdam, The Netherlands, NL aut NATIONALLICENCE 700 1- Bouter L. M. Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer