caa a22 4500 475772741 CHVBK 20180406123622.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s001250051355 doi (NATIONALLICENCE)springer-10.1007/s001250051355 The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation [Elektronische Daten] [M. E. Cooper, V. Thallas, J. Forbes, E. Scalbert, S. Sastra, I. Darby, T. Soulis] Aims/hypothesis. Advanced glycation is postulated to have a pivotal role in mediating diabetic vascular complications. The emergence of thiazolium compounds such as N-phenacylthiazolium bromide which cleave preformed advanced glycation end products (AGEs) has allowed us to explore the effects of these agents on the vascular AGE accumulation and hypertrophy associated with diabetes. Methods. Control and streptozotocin diabetic rats were selected at random for no treatment or treatment with N-phenacylthiazolium bromide (10 mg/kg intraperitoneally) and followed for 3 weeks. In a separate study, intervention with N-phenacylthiazolium bromide was delayed until after 3 weeks of diabetes and then given for 3 weeks (total of 6 weeks). Results. Diabetes was associated with increased mesenteric vascular advanced glycation end products, as assessed by radioimmunoassay and immunohistochemistry. This increase in vascular AGE accumulation was prevented by N-phenacylthiazolium bromide treatment. Diabetes-associated mesenteric vascular hypertrophy was attenuated by treatment with N-phenacylthiazolium bromide only if given from the time of induction of diabetes. Conclusion/interpretation. Cross-link breakers seem to be effective in preventing or reversing accumulation of advanced glycation end-products in blood vessels and have the potential to play a part in the treatment of diabetic vascular complications. [Diabetologia (2000) 43: 660-664] Springer-Verlag Berlin Heidelberg, 2000 Keywords Glycation nationallicence vascular nationallicence thiazolium nationallicence cross-link breaker nationallicence Cooper M. E. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut Thallas V. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut Forbes J. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut Scalbert E. IRIS, Courbevoie, France, FR aut Sastra S. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut Darby I. Department of Human Biology, Royal Melbourne Institute of Technology, Bundoora Campus, Bundoora, Australia, AU aut Soulis T. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut https://doi.org/10.1007/s001250051355 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051355 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cooper M. E. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut NATIONALLICENCE 700 1- Thallas V. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut NATIONALLICENCE 700 1- Forbes J. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut NATIONALLICENCE 700 1- Scalbert E. IRIS, Courbevoie, France, FR aut NATIONALLICENCE 700 1- Sastra S. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut NATIONALLICENCE 700 1- Darby I. Department of Human Biology, Royal Melbourne Institute of Technology, Bundoora Campus, Bundoora, Australia, AU aut NATIONALLICENCE 700 1- Soulis T. Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer