caa a22 4500 475772806 CHVBK 20180406123622.0 cr unu---uuuuu 170329e20000501xx s 000 0 eng 10.1007/s001250051345 doi (NATIONALLICENCE)springer-10.1007/s001250051345 The effect of acute hyperglycaemia on QTc duration in healthy man [Elektronische Daten] [R. Marfella, F. Nappo, L. De Angelis, M. Siniscalchi, F. Rossi, D. Giugliano] Aims/hypothesis. Prolongation of heart rate-adjusted QT (QTc) is associated with an increased risk of coronary heart disease and sudden death. The objective of this study was to investigate whether acute increases of plasma glucose concentrations in healthy subjects could influence QTc and QTc dispersion. Methods. Plasma glucose concentrations were quickly raised to 15 mmol/l in 20 healthy subjects (10 men/10 women) and maintained for 2 h. On another occasion, and in random order, all subjects underwent the same hyperglycaemic clamp as above and an infusion of the somatostatin analogue octreotide (25 μg as iv bolus followed by a 0.5 g/min infusion) to block the release of endogenous insulin. Results. Systolic and diastolic blood pressures, heart rate and plasma catecholamine concentrations showed significant increases (p < 0.05) starting after 60 min of hyperglycaemia. QTc, QTc dispersion and PR interval also showed significant increments at 120 min of the hyperglycaemic clamp. The infusion of octreotide did not influence QTc duration, QTc dispersion, PR interval and the haemodynamic effects of acute hyperglycaemia. Conclusion/interpretation. The results show that acute hyperglycaemia produces significant increments of QTc and QTc dispersion in normal subjects. In this context, endogenously released insulin during acute hyperglycaemia seems to play a minor part. [Diabetologia (2000) 43: 571-575] Springer-Verlag Berlin Heidelberg, 2000 Keywords Acute hyperglycaemia nationallicence healthy subjects nationallicence QTc duration nationallicence QTc dispersion nationallicence hyperinsulinaemia nationallicence octreotide nationallicence Marfella R. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut Nappo F. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut De Angelis L. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut Siniscalchi M. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut Rossi F. Institute of Pharmacology and Toxicology, Second University of Naples, Italy, IT aut Giugliano D. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut https://doi.org/10.1007/s001250051345 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051345 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marfella R. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut NATIONALLICENCE 700 1- Nappo F. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut NATIONALLICENCE 700 1- De Angelis L. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut NATIONALLICENCE 700 1- Siniscalchi M. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut NATIONALLICENCE 700 1- Rossi F. Institute of Pharmacology and Toxicology, Second University of Naples, Italy, IT aut NATIONALLICENCE 700 1- Giugliano D. Department of Geriatrics and Metabolic Diseases, Second University of Naples, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer