caa a22 4500 475772911 CHVBK 20180406123622.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s001250050022 doi (NATIONALLICENCE)springer-10.1007/s001250050022 Nitric oxide and vascular responses in Type I diabetes [Elektronische Daten] [N. N. Chan, P. Vallance, H. M. Colhoun] Vascular complications are major causes of morbidity and mortality in patients with diabetes mellitus. The mechanisms underlying the development of microvascular and macrovascular angiopathy in Type I (insulin-dependent) diabetes mellitus are complex and incompletely understood. The discovery of endothelium-derived nitric oxide has greatly improved our understanding of vascular biology. Nitric oxide has an important role in the regulation of vascular tone and impaired nitric oxide activity could be implicated in the development of diabetic vasculopathy. Vascular studies of endothelial function in Type I diabetes have produced conflicting results. The role of nitric oxide in diabetic vasculopathy is still not clear. [Diabetologia (2000) 43: 137-147] Springer-Verlag Berlin Heidelberg, 2000 Keywords Type I diabetes, nitric oxide, endothelium, vasodilatation, plethysmography, flow-mediated dilatation, vascular ultrasound nationallicence Chan N. N. EURODIAB Department of Epidemiology and Public-Health, University College London, UK, GB aut Vallance P. Department of Clinical Pharmacology, University College London, UK, GB aut Colhoun H. M. EURODIAB Department of Epidemiology and Public-Health, University College London, UK, GB aut https://doi.org/10.1007/s001250050022 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050022 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chan N. N. EURODIAB Department of Epidemiology and Public-Health, University College London, UK, GB aut NATIONALLICENCE 700 1- Vallance P. Department of Clinical Pharmacology, University College London, UK, GB aut NATIONALLICENCE 700 1- Colhoun H. M. EURODIAB Department of Epidemiology and Public-Health, University College London, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer