caa a22 4500 475772946 CHVBK 20180406123622.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s001250050024 doi (NATIONALLICENCE)springer-10.1007/s001250050024 Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study [Elektronische Daten] [E. Bonora, S. Kiechl, F. Oberhollenzer, G. Egger, R. C. Bonadonna, M. Muggeo, J. Willeit] Abstracts : Aims/hypothesis. Cardiovascular disease is a well-known severe complication of impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus. The independent contribution of glucose intolerance to cardiovascular disease and the underlying pathogenic mechanisms are still, however, not clear.¶Methods. In this prospective population-based study, 826 subjects aged 40-79 years underwent high resolution duplex ultrasound examinations of carotid arteries and extensive clinical and laboratory screenings for potential vascular risk factors at baseline and 5 years later. The ultrasound protocol involved measurements of maximum axial diameter of atherosclerotic plaques, if any, in common and internal carotid arteries on both sides and enable differentiation of two main stages in carotid artery disease, termed early non-stenotic and advanced stenotic atherosclerosis. Intima-media thickness was assessed at the follow-up examination.¶Results. Type II diabetes and, to a lesser extent, impaired glucose tolerance were found to be statistically significant risk predictors of 5-year changes in carotid atherosclerosis. These associations were in part independent of other vascular risk factors typically clustering with glucose intolerance. Both impaired glucose tolerance and Type II diabetes mellitus were not independently related to early non-stenotic atherosclerosis. In contrast, Type II diabetes mellitus was the strongest single risk predictor of advanced stenotic atherosclerosis [odds ratio 5.0 (95 % confidence intervals 2.3-11.1)] and impaired glucose tolerance was of relevance as well [odds ratio 2.8 (1.2-6.4)] (p < 0.001).¶Conclusion/interpretation. Impaired glucose tolerance and, to a greater extent, Type II diabetes were strong independent predictors of advanced carotid atherosclerosis in our prospective population-based study. [Diabetologia (2000) 43: 156-164] Springer-Verlag Berlin Heidelberg, 2000 Keywords Impaired glucose tolerance, Type II diabetes mellitus, atherosclerosis, carotid arteries, cardiovascular risk factors nationallicence Bonora E. Department of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy, IT aut Kiechl S. Department of Neurology, University of Innsbruck Medical School, Innsbruck, Austria, AT aut Oberhollenzer F. Department of Internal Medicine, Hospital of Bruneck, Bruneck, Italy, IT aut Egger G. Department of Internal Medicine, Hospital of Bruneck, Bruneck, Italy, IT aut Bonadonna R. C. Department of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy, IT aut Muggeo M. Department of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy, IT aut Willeit J. Department of Neurology, University of Innsbruck Medical School, Innsbruck, Austria, AT aut https://doi.org/10.1007/s001250050024 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050024 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bonora E. Department of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy, IT aut NATIONALLICENCE 700 1- Kiechl S. Department of Neurology, University of Innsbruck Medical School, Innsbruck, Austria, AT aut NATIONALLICENCE 700 1- Oberhollenzer F. Department of Internal Medicine, Hospital of Bruneck, Bruneck, Italy, IT aut NATIONALLICENCE 700 1- Egger G. Department of Internal Medicine, Hospital of Bruneck, Bruneck, Italy, IT aut NATIONALLICENCE 700 1- Bonadonna R. C. Department of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy, IT aut NATIONALLICENCE 700 1- Muggeo M. Department of Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy, IT aut NATIONALLICENCE 700 1- Willeit J. Department of Neurology, University of Innsbruck Medical School, Innsbruck, Austria, AT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer