caa a22 4500 475772954 CHVBK 20180406123622.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s001250050034 doi (NATIONALLICENCE)springer-10.1007/s001250050034 Comparison of progression of macrovascular diseases after kidney or pancreas and kidney transplantation in diabetic patients with end-stage renal disease [Elektronische Daten] [G. Biesenbach, R. Margreiter, A. Königsrainer, C. Bösmüller, O. Janko, P. Brücke, C. Gross, J Zazgornik] Aims/hypothesis . The aim of the study was to examine the effect of pancreas-kidney transplantation on the progression of macrovascular diseases in Type I diabetic patients with end-stage renal disease.¶Methods . The progression of cerebrovascular disease, coronary heart disease and peripheral vascular disease in uraemic patients with Type I (insulin-dependent) diabetes mellitus and who had had simultaneous pancreas-kidney transplantation was compared with that of recipients of a kidney transplant alone. Between 1986 and 1998 a total of 11 uraemic diabetic patients received a simultaneous pancreas-kidney transplantation and 10 diabetic patients a kidney transplant alone. All transplants functioned for at least 24 months, the mean observation period was 69 ± 37 compared with 70 ± 33 months in both patient groups. Macroangiopathic diseases were classified in four stages as described earlier.¶Results. In the group with simultaneous pancreas-kidney transplantation progression of cerebrovascular and coronary heart disease was observed in four patients (36 %) and progression of peripheral vascular disease in five subjects (45 %). In the cohort with kidney transplant alone four patients (40 %) showed progression of cerebrovascular and coronary heart disease and five progression of peripheral vascular disease (50 %); the difference is not significant. Mean values of HbA1 c (5.8 ± 0.2 vs 7.5 ± 0.6 %, p < 0.001) and serum triglycerides (1.2 ± 0.4 vs 2.0 ± 1.0 mmol/l, p < 0.05) were significantly lower in the patients with pancreas-kidney transplantation than in the patient group with kidney transplant alone. Serum cholesterol concentrations and blood pressures were similar in both cohorts.¶Conclusion/interpretation. From our results we concluded that pancreas-kidney transplantation reduces risk factors for the development of macroangiopathy but fails to halt progression of macrovascular diseases similar to Type I diabetic patients with kidney transplant alone. [Diabetologia (2000) 43: 231-234] Springer-Verlag Berlin Heidelberg, 2000 Keywords Type I diabetes, pancreas-kidney transplantation, macroangiopathic diseases nationallicence Biesenbach G. Second Department of Medicine, General Hospital, Linz, Austria, AT aut Margreiter R. Department of Transplant Surgery, University Hospital, Innsbruck, Austria, AT aut Königsrainer A. Department of Transplant Surgery, University Hospital, Innsbruck, Austria, AT aut Bösmüller C. Department of Transplant Surgery, University Hospital, Innsbruck, Austria, AT aut Janko O. Second Department of Medicine, General Hospital, Linz, Austria, AT aut Brücke P. First Department of Surgery, General Hospital Linz, Austria, AT aut Gross C. First Department of Surgery, General Hospital Linz, Austria, AT aut Zazgornik J. Second Department of Medicine, General Hospital, Linz, Austria, AT aut https://doi.org/10.1007/s001250050034 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050034 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biesenbach G. Second Department of Medicine, General Hospital, Linz, Austria, AT aut NATIONALLICENCE 700 1- Margreiter R. Department of Transplant Surgery, University Hospital, Innsbruck, Austria, AT aut NATIONALLICENCE 700 1- Königsrainer A. Department of Transplant Surgery, University Hospital, Innsbruck, Austria, AT aut NATIONALLICENCE 700 1- Bösmüller C. Department of Transplant Surgery, University Hospital, Innsbruck, Austria, AT aut NATIONALLICENCE 700 1- Janko O. Second Department of Medicine, General Hospital, Linz, Austria, AT aut NATIONALLICENCE 700 1- Brücke P. First Department of Surgery, General Hospital Linz, Austria, AT aut NATIONALLICENCE 700 1- Gross C. First Department of Surgery, General Hospital Linz, Austria, AT aut NATIONALLICENCE 700 1- Zazgornik J. Second Department of Medicine, General Hospital, Linz, Austria, AT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer