caa a22 4500 475773055 CHVBK 20180406123623.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s001250050036 doi (NATIONALLICENCE)springer-10.1007/s001250050036 Association of -3826 G Variant in uncoupling protein-1 with increased BMI in overweight Australian women [Elektronische Daten] [L. K. Heilbronn, K. L. Kind, E. Pancewicz, A. M. Morris, M. Noakes, P. M. Clifton] Aims/hypothesis. To determine whether genetic variation in uncoupling protein-1 (UCP-1) is associated with obesity or obesity-related risk factors in overweight women.¶Methods. We genotyped 526 overweight/obese women (mean body mass index 34.1 kg/m2, range 25.0 to 47.5 kg/m2) for the -3826 A→G uncoupling protein-1 polymorphism. Of the 526 women genotyped 144 had fasting blood samples analysed for glucose and lipid measurements.¶Results. The -3826 G allele was found with a frequency of 0.23 and was associated with higher BMI (p = 0.02). A higher frequency of this polymorphism (0.33) was found in subjects with Type II (non-insulin-dependent) diabetes mellitus (p = 0.02), though adjustment for BMI weakened this significance (p = 0.06). The -3826 G variant was associated with increased fasting glucose (p = 0.01). This was, however, a result of a greater proportion of women with Type II diabetes also having the G variant (p = 0.10, adjusted for Type II diabetes). The -3826 G variant of uncoupling protein-1 did not have an effect on other metabolic variables associated with obesity.¶Conclusion/interpretation. In overweight Australian women the -3826 G variant of UCP-1 increased the susceptibility to obesity indicating that UCP-1 could be involved in weight regulation. [Diabetologia (2000) 43: 242-244] Springer-Verlag Berlin Heidelberg, 2000 Keywords Uncoupling protein-1, polymorphism, obesity, Type II diabetes nationallicence Heilbronn L. K. Department of Physiology, University of Adelaide, South Australia, AU aut Kind K. L. Commonwealth Scientific Industrial Research Organization (CSIRO) Health Sciences and Nutrition, Adelaide, South Australia, AU aut Pancewicz E. Department of Physiology, University of Adelaide, South Australia, AU aut Morris A. M. Department of Physiology, University of Adelaide, South Australia, AU aut Noakes M. Commonwealth Scientific Industrial Research Organization (CSIRO) Health Sciences and Nutrition, Adelaide, South Australia, AU aut Clifton P. M. Commonwealth Scientific Industrial Research Organization (CSIRO) Health Sciences and Nutrition, Adelaide, South Australia, AU aut https://doi.org/10.1007/s001250050036 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250050036 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Heilbronn L. K. Department of Physiology, University of Adelaide, South Australia, AU aut NATIONALLICENCE 700 1- Kind K. L. Commonwealth Scientific Industrial Research Organization (CSIRO) Health Sciences and Nutrition, Adelaide, South Australia, AU aut NATIONALLICENCE 700 1- Pancewicz E. Department of Physiology, University of Adelaide, South Australia, AU aut NATIONALLICENCE 700 1- Morris A. M. Department of Physiology, University of Adelaide, South Australia, AU aut NATIONALLICENCE 700 1- Noakes M. Commonwealth Scientific Industrial Research Organization (CSIRO) Health Sciences and Nutrition, Adelaide, South Australia, AU aut NATIONALLICENCE 700 1- Clifton P. M. Commonwealth Scientific Industrial Research Organization (CSIRO) Health Sciences and Nutrition, Adelaide, South Australia, AU aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer