caa a22 4500 47577311X CHVBK 20180406123623.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s001250051549 doi (NATIONALLICENCE)springer-10.1007/s001250051549 An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort [Elektronische Daten] [A. Meirhaeghe, P. Amouyel, N. Helbecque, D. Cottel, S. Otabe, P. Froguel, F. Vasseur] Aims/hypothesis. The UCP2-UCP3 gene region has been previously associated with obesity and diabetes. In a large representative cohort of Northern France (MONICA project), we studied the effect of a recently reported C/T polymorphism located in the 5' sequences of the UCP3 gene on anthropometric measurements and lipid profile. We also examined the association of this polymorphism with obesity and Type II (non-insulin-dependent) diabetes mellitus.¶Methods. The -55 C/T polymorphism of the UCP3 gene has been genotyped in 1155 subjects from the MONICA project. Association studies were done with diabetes, obesity and related phenotypes. Results were ascertained in a second cohort of well-characterized Type II diabetic and control subjects.¶Results. The variant T allele was associated with a decreased risk of developing Type II diabetes. Frequencies of the T allele were 13.3 % compared with 22 %, p = 0.04, in the diabetic and control groups, respectively. This observation was confirmed in the second cohort of French Type II diabetic (n = 171) and control (n = 124) subjects: 17.8 % compared with 25 %, p = 0.03. Moreover, subjects bearing the TT genotype had higher plasma total cholesterol and LDL-cholesterol concentrations (p = 0.0006 and p = 0.001, respectively) than subjects bearing wild or heterozygous genotypes.¶Conclusion/interpretation. The UCP3-55 C/T polymorphism was associated with a higher atherogenic profile and modified the risk for the development of Type II diabetes. [Diabetologia (2000) 43: 1424-1428] Springer-Verlag Berlin Heidelberg, 2000 Keywords Uncoupling protein (UCP), polymorphism, Type II diabetes, obesity nationallicence Meirhaeghe A. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut Amouyel P. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut Helbecque N. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut Cottel D. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut Otabe S. Institute of Biology of Lille, CNRS UPRES A 8090, Central Hospital and University of Lille (CHRU), Lille, France, FR aut Froguel P. Institute of Biology of Lille, CNRS UPRES A 8090, Central Hospital and University of Lille (CHRU), Lille, France, FR aut Vasseur F. Institute of Biology of Lille, CNRS UPRES A 8090, Central Hospital and University of Lille (CHRU), Lille, France, FR aut https://doi.org/10.1007/s001250051549 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051549 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meirhaeghe A. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut NATIONALLICENCE 700 1- Amouyel P. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut NATIONALLICENCE 700 1- Helbecque N. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut NATIONALLICENCE 700 1- Cottel D. Department of Epidemiology and Public Health - INSERM U.508, Pasteur Institute of Lille, Central Hospital and University of Lille (CHRU), Lille, France, FR aut NATIONALLICENCE 700 1- Otabe S. Institute of Biology of Lille, CNRS UPRES A 8090, Central Hospital and University of Lille (CHRU), Lille, France, FR aut NATIONALLICENCE 700 1- Froguel P. Institute of Biology of Lille, CNRS UPRES A 8090, Central Hospital and University of Lille (CHRU), Lille, France, FR aut NATIONALLICENCE 700 1- Vasseur F. Institute of Biology of Lille, CNRS UPRES A 8090, Central Hospital and University of Lille (CHRU), Lille, France, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer