caa a22 4500 475773179 CHVBK 20180406123623.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s001250051538 doi (NATIONALLICENCE)springer-10.1007/s001250051538 Differences in HDL-cholesterol:apoA-I + apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients [Elektronische Daten] [S. S. Soedamah-Muthu, H. M. Colhoun, M.-R. Taskinen, B. Idzior-Walus, J. H. Fuller] Aims/hypothesis. To examine whether the HDL-cholesterol:apoA-I + apoA-II ratio and the ɛ2 allele are related to albuminuria at baseline and whether they are risk factors for progression of albuminuria in a cohort study of patients with Type I (insulin-dependent) diabetes mellitus.¶Methods. At baseline, the study cohort comprised 617 patients, aged 15-60 years, from seven European diabetic centres of the EURODIAB study. Albumin excretion rate, measured in a central laboratory, was categorised as normoalbuminuria at 20 μg/min or less, microalbuminuria between 20 and 200 μg/min or macroalbuminuria at 200 μg/min or over. Of the 250 patients who were normoalbuminuric at baseline and had follow-up albuminuria measurements, 34 patients were defined as early progressors.¶Results. At baseline, the mean HDL-cholesterol:apoA-I + apoA-II ratio was lower in macroalbuminuric patients (0.79, 95 % CI:0.74-0.83) compared with normoalbuminuric (0.88, 95 % CI:0.87-0.90) patients (p = 0.0002, adjusted for age and sex). At follow-up, 34 patients who progressed from normoalbuminuria to microalbuminuria or macroalbuminuria also had a slightly lower baseline ratio (0.85, 95 % CI:0.80-0.89) than those 216 who remained normoalbuminuric (0.89, 95 % CI:0.87-0.92) (adjusted p = 0.08). Neither of these relations were independent of LDL-cholesterol or fasting triglyceride. There was no association of the ɛ2 allele with albuminuria either at baseline (OR = 1.4, 95 % CI:0.7-2.8) or with progression of albuminuria (OR = 0.4, 95 % CI:0.1-3.5).¶Conclusion/interpretation. There is an inverse relation of HDL-cholesterol:apoA-I + apoA-II ratio with albuminuria at baseline. This lower ratio in microalbuminuric or macroalbuminuric patients could contribute to the increased risk of cardiovascular disease associated with nephropathy. There is weak evidence that HDL-composition is a risk factor for progression of albuminuria and no association of the ɛ2 allele with diabetic nephropathy. [Diabetologia 2000 43: 1353-1359] Springer-Verlag Berlin Heidelberg, 2000 Keywords HDL-cholesterol, apolipoprotein E phenotype, ɛ2 allele, apolipoproteins, albuminuria, Type I diabetes, apolipoprotein A-I, apolipoprotein A-II, diabetic nephropathy, progression nationallicence Soedamah-Muthu S. S. EURODIAB, Royal Free and UCL medical school, London, UK, GB aut Colhoun H. M. EURODIAB, Royal Free and UCL medical school, London, UK, GB aut Taskinen M.-R University of Helsinki, Department of Medicine, Helsinki, Finland, FI aut Idzior-Walus B. Jagiellonian University, Krakow, Poland, PL aut Fuller J. H. EURODIAB, Royal Free and UCL medical school, London, UK, GB aut https://doi.org/10.1007/s001250051538 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001250051538 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Soedamah-Muthu S. S. EURODIAB, Royal Free and UCL medical school, London, UK, GB aut NATIONALLICENCE 700 1- Colhoun H. M. EURODIAB, Royal Free and UCL medical school, London, UK, GB aut NATIONALLICENCE 700 1- Taskinen M.-R University of Helsinki, Department of Medicine, Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Idzior-Walus B. Jagiellonian University, Krakow, Poland, PL aut NATIONALLICENCE 700 1- Fuller J. H. EURODIAB, Royal Free and UCL medical school, London, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer