caa a22 4500 475773446 CHVBK 20180406123624.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1023/A:1007160202229 doi (NATIONALLICENCE)springer-10.1023/A:1007160202229 Observations on EGFR gene amplification and polymorphism in prostatic diseases [Elektronische Daten] [V.L. Kumar, P.K. Majumder, V. Kumar] This study was designed to determine the amplification and polymorphism of epidermal growth factor receptor (EGFR) gene in prostatic diseases like benign hypertrophy (BPH) and carcinoma (CaP). The EGFR gene was found to be amplified in grade IV BPH as compared to grade II BPH. Digestion of genomic DNA with MspI and HpaII revealed the presence of a 5kb band following southern blot analysis. This 5kb band was present in all the CaP cases and in one out of three BPH cases. It is possible that such a polymorphism is associated with the type or extent of tumor progression. Kluwer Academic Publishers, 2000 Benign tumor nationallicence Carcinoma nationallicence Prostate nationallicence Kumar V.L. Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Majumder P.K. Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut Kumar V. Virology group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India aut International Urology and Nephrology Kluwer Academic Publishers 32/1(2000-03-01), 73-75 0301-1623 32:1<73 2000 32 11255 https://doi.org/10.1023/A:1007160202229 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007160202229 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kumar V.L. Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Majumder P.K. Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India aut NATIONALLICENCE 700 1- Kumar V. Virology group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India aut NATIONALLICENCE 773 0- International Urology and Nephrology Kluwer Academic Publishers 32/1(2000-03-01), 73-75 0301-1623 32:1<73 2000 32 11255 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer