caa a22 4500 47577373X CHVBK 20180406123624.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1007135118519 doi (NATIONALLICENCE)springer-10.1023/A:1007135118519 N-acetyl-glucosaminidase (NAG) excretion in partially obstructed weanling rats [Elektronische Daten] [M. De Gennaro, M. Silveri, M.L. Capitanucci, A. Silvano, F. Colistro, A. Villani, A. Zaccara] The understanding of pathophysiology of obstructed uropathy has been facilitated by animal models with partial ureteric obstruction. Some studies on partially obstructed adult rats have drawn attention to a biphasic pattern of obstructive uropathy: an initial 'sdestructive' phase and a 'ssteady' phase in which renal deterioration no longer occurs and in which relief of obstruction would be of no advantage. We aimed to verify if this pattern applies also to younger (weanling) rats with more immature kidneys, resembling those of the human fetus. We measured the NAG-values in the urine samples of partially obstructed animals at different intervals of obstruction and in those of controls. The biphasic pattern proved to be the same as in adult rats as was previously documented, but the turning point occurred earlier (between 10 and 15 days of obstruction). Furthermore, there is evidence of low level values of N-Acetyl-Glucosaminidase (NAG) in the early phase of obstruction (5 days), demonstring that the increase of tubular enzyme is not due to the operation itself. There is evidence that, if the 'sdestructive' phase can be precisely identified by biochemical studies, this could help identifying those subjects who could benefit from relief of obstruction. Kluwer Academic Publishers, 2000 N-acetyl-glucosaminidase (NAG) nationallicence Obstructive uropathy nationallicence Weanling rats nationallicence De Gennaro M. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut Silveri M. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut Capitanucci M.L. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut Silvano A. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut Colistro F. Department of Biochemistry, Bambino Gesù Children's Hospital, Rome, Italy aut Villani A. Department of Anesthesiology, Bambino Gesù Children's Hospital, Rome, Italy aut Zaccara A. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 215-218 0301-1623 32:2<215 2000 32 11255 https://doi.org/10.1023/A:1007135118519 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007135118519 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Gennaro M. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut NATIONALLICENCE 700 1- Silveri M. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut NATIONALLICENCE 700 1- Capitanucci M.L. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut NATIONALLICENCE 700 1- Silvano A. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut NATIONALLICENCE 700 1- Colistro F. Department of Biochemistry, Bambino Gesù Children's Hospital, Rome, Italy aut NATIONALLICENCE 700 1- Villani A. Department of Anesthesiology, Bambino Gesù Children's Hospital, Rome, Italy aut NATIONALLICENCE 700 1- Zaccara A. Department of Pediatric Surgery, Bambino Gesù Children's Hospital, Rome, Italy aut NATIONALLICENCE 773 0- International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 215-218 0301-1623 32:2<215 2000 32 11255 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer