caa a22 4500 475773748 CHVBK 20180406123624.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1007118210759 doi (NATIONALLICENCE)springer-10.1023/A:1007118210759 The distribution of S-100 protein in hyperplastic and neoplastic prostatic epithelium [Elektronische Daten] [C. Constantinides, Th. Manousakas, K. Pavlaki, D. Zizi, G. Kyriakou, Ch. Alamanis, C. Dimopoulos] Specimens from 30 cases of benign prostatichyperplasia and 75 cases of prostatic carcinomaobtained during suprapubic prostatectomy, transurethalresection of the prostate and radical prostatectomy,were stained immunohistochemically for S-100 protein,prostatic acid phosphatase (PAP), prostatic specificantigen (PSA), neuron specific enolase (NSE) andpolyclonal keratin. S-100 protein was positive in9.3% of prostatic carcinomas and negative in allcases of prostatic hyperplasia. PAP and PSA werepositive in all cases, while NSE was positive in 16%of the carcinoma cases. Polyclonal keratin waspositive in both cell layers of the double layeredhyperplastic prostatic epithelium with a more intensestaining pattern in the outer cell layer. The authorsbelieve that the S-100 protein immunoreactivityobserved in some prostatic carcinomas, reflecting thechange in the functional status of the neoplasticcells, might be of prognostic significance. They alsoemphasize the non-myoepithelial nature of the outercell layer of the double layered prostaticepithelium. Kluwer Academic Publishers, 2000 Benign prostatic hyperplasia nationallicence Immunohistochemistry nationallicence Prostatic adenocarcinoma nationallicence S-100 protein nationallicence Constantinides C. Departments of Urology, Athens University Medical School, Athens, Greece aut Manousakas Th Departments of Urology, Athens University Medical School, Athens, Greece aut Pavlaki K. Departments of Pathology, Athens University Medical School, Athens, Greece aut Zizi D. Department of Pathology, Tzanion Hospital, Piraeus, Greece aut Kyriakou G. Departments of Urology, Athens University Medical School, Athens, Greece aut Alamanis Ch Departments of Urology, Athens University Medical School, Athens, Greece aut Dimopoulos C. Departments of Urology, Athens University Medical School, Athens, Greece aut International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 259-261 0301-1623 32:2<259 2000 32 11255 https://doi.org/10.1023/A:1007118210759 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007118210759 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Constantinides C. Departments of Urology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Manousakas Th Departments of Urology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Pavlaki K. Departments of Pathology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Zizi D. Department of Pathology, Tzanion Hospital, Piraeus, Greece aut NATIONALLICENCE 700 1- Kyriakou G. Departments of Urology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Alamanis Ch Departments of Urology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Dimopoulos C. Departments of Urology, Athens University Medical School, Athens, Greece aut NATIONALLICENCE 773 0- International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 259-261 0301-1623 32:2<259 2000 32 11255 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer