caa a22 4500 475773837 CHVBK 20180406123625.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1007123725297 doi (NATIONALLICENCE)springer-10.1023/A:1007123725297 Beneficial effect of verapamil added to chronic ACE inhibitor treatment on renal function in hypertensive elderly patients [Elektronische Daten] [Reda Bitar, Olga Flores, María Reverte, José López-Novoa, Juan Macías] This study analysed the effect of low doses ofverapamil added to chronic treatment withangiotensin-converting enzyme (ACE) inhibitors onblood pressure and serum creatinine levels in eightelderly hypertensive patients who had a steadyincrease of serum creatinine while on ACE inhibitors.The study was performed in eight elderly hypertensivesubjects, five men and three women (mean age 70 ±2 years; systolic blood pressure 173 ± 4 mmHg; diastolic blood pressure 99 ± 1 mm Hg) andserum creatinine of 1.60 ± 0.27 mg/dl beforetreatment. During an average of 25 weeks, ACEinhibitors significantly reduced both systolic anddiastolic blood pressures, but serum creatinine levelswere increased over basal levels (0,68 ± 0,20 mg/dl, p < 0.05). During an average of 10 weeks,the addition of verapamil did not decrease bloodpressure further, but serum creatinine levels werereduced to baseline. Our study suggests that theaddition of verapamil to ACE inhibitors can reverseACE-induced increase in creatinine levels in elderlyhypertensive patients in whom this side effect isobserved. Kluwer Academic Publishers, 2000 Angiotensing-converting enzyme inhibitor nationallicence Elderly nationallicence Hypertension nationallicence Non-dihydropyridine calcium channel blocker nationallicence Serum creatinine nationallicence Verapamil nationallicence Bitar Reda Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut Flores Olga Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut Reverte María Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut López-Novoa José Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut Macías Juan Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 165-169 0301-1623 32:2<165 2000 32 11255 https://doi.org/10.1023/A:1007123725297 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007123725297 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bitar Reda Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut NATIONALLICENCE 700 1- Flores Olga Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut NATIONALLICENCE 700 1- Reverte María Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut NATIONALLICENCE 700 1- López-Novoa José Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut NATIONALLICENCE 700 1- Macías Juan Instituto Reina Sofía de Investigación Nefrológica and Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain aut NATIONALLICENCE 773 0- International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 165-169 0301-1623 32:2<165 2000 32 11255 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer