caa a22 4500 475773896 CHVBK 20180406123625.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1007100306404 doi (NATIONALLICENCE)springer-10.1023/A:1007100306404 Renal transplantation in patients above 60 years of age in the modern era: A single center experience with a review of the literature [Elektronische Daten] [Amit Basu, Stuart Greenstein, Suzanne Clemetson, Melinda Mallis, Dean Kim, Richard Schechner, Paul Gerst, Vivian Tellis] A retrospective study was conducted of 797 patients receiving renal transplants from January 1985 to March 1997. Patient and graft survival was compared for patients above and below the age of 60. Sixty-ninepatients ≤60 years old received 73 kidneys. Race: 73% Caucasian, 26% Black, 1% Other. Sex: 68%M. Hypertension (19) and PCKD (15) were the most common diagnoses. Mean peak panel reactive antibody (PRA) was 37.7%. Donor age was 2 to 66 years. Mean Cold ischemic time was 28.1 hours. Follow-up was untildeath or until 8/30/97. Patients <60 years included:62% Caucasian, 34% Black, 4% Other, 60% male, Mean PRA 39.3. Of the 69 study patients, 27 died: 19 with afunctioning graft, 8 within one year oftransplantation. Cardiovascular causes (19 patients,72%) and infection (7 patients, 24%) were mostcommon. Common causes of graft loss were death witha functioning graft (19) and chronic rejection (15);other causes were acute rejection and primarynon-function. Univariate analysis of 18 risk factorsshowed CHF and past history of vascular surgerysignificantly (p < 0.05) affected time of return todialysis. Multi variate analysis did not show theseindependent variables to be significant. Abnormalejection fraction and presence of q waves on EKGsignificantly affected time to death (p < 0.05) on uniand multi-variate analysis. After censoring patientsthat died with functioning grafts, difference in graftsurvival between ≥60 and <59 years was notsignificant (p > 0.2). In this study, 68% of older patients had allograftsfunctioning at 1 year. The fact that older patientssuccumb over time from natural causes should not keeppatients from transplantation. Immunosuppressiveagents need to be limited to reduce the incidence ofinfection. Criteria need to be refined to define thosewho are at prohibitive risk, who may not be candidatesfor transplantation. Kluwer Academic Publishers, 2000 Cardiac risk factors nationallicence Elderly nationallicence Renal transplantation nationallicence Basu Amit Department of Surgery Bronx Lebanon Medical Center, Bronx, New York, USA aut Greenstein Stuart Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut Clemetson Suzanne Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut Mallis Melinda Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut Kim Dean Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut Schechner Richard Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut Gerst Paul Department of Surgery Bronx Lebanon Medical Center, Bronx, New York, USA aut Tellis Vivian Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 171-176 0301-1623 32:2<171 2000 32 11255 https://doi.org/10.1023/A:1007100306404 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007100306404 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Basu Amit Department of Surgery Bronx Lebanon Medical Center, Bronx, New York, USA aut NATIONALLICENCE 700 1- Greenstein Stuart Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut NATIONALLICENCE 700 1- Clemetson Suzanne Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut NATIONALLICENCE 700 1- Mallis Melinda Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut NATIONALLICENCE 700 1- Kim Dean Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut NATIONALLICENCE 700 1- Schechner Richard Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut NATIONALLICENCE 700 1- Gerst Paul Department of Surgery Bronx Lebanon Medical Center, Bronx, New York, USA aut NATIONALLICENCE 700 1- Tellis Vivian Department of Surgery Montefiore Medical Center, Bronx, New York, USA aut NATIONALLICENCE 773 0- International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 171-176 0301-1623 32:2<171 2000 32 11255 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer