caa a22 4500 47577390X CHVBK 20180406123625.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1007110624151 doi (NATIONALLICENCE)springer-10.1023/A:1007110624151 Treatment of hypertension with valsartan combined with spironolactone [Elektronische Daten] [Aurelio Leone, Franco Bertanelli, Lino Mori] Preliminary observations were made to assess theantihypertensive efficacy and safety of treatmentwith valsartan plus spironolactone. Thirteenhypertensive patients were studied, 7 were males(54%), and 6 females (46%) with an age range from 61years to 83 years (mean: 74±7.1 years). Patients had amean daytime SBP / DBP of 164±9.2 / 99±9.5 mmHg.Echocardiography showed cardiac hypertrophy and mildcavity enlargement in all patients. After baselinemeasurements of HR, serum creatinine and electrolytes(potassium and sodium), patients received valsartan80 mg/day plus spironolactone 100 mg/day forconcomitant chronic heart failure due tohypertension. Study parameters were measured at the 30, 60, and 90 day of therapy. Mean ambulatory SBP/DBP monitoring, mean Holter heart rate, mean serumcreatinine, and mean serum electrolytes (sodium andpotassium) were recorded. These parameters did notshow statistically significant changes after 90 daysof follow up, except in one patient who had anincrease in serum potassium concentration from 4.3mmol/l to 5.8 mmol/l after 30 days of therapy. MeanBP was reduced up a maximum of 7%. No side effectwas seen in the study patients. Combination therapyvalsartan and spironolactone seemed to be aneffective and safe approach for older hypertensivepatients with mild concomitant chronic heart failure. Kluwer Academic Publishers, 2000 Hypertension nationallicence Spironolactone nationallicence Valsartan nationallicence Leone Aurelio Division of Medicine City Hospital Massa, ASL 1, Massa e Carrara, Italy aut Bertanelli Franco Division of Medicine City Hospital Pontremoli, ASL 1, Massa e Carrara, Italy aut Mori Lino Division of Medicine City Hospital Pontremoli, ASL 1, Massa e Carrara, Italy aut International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 161-163 0301-1623 32:2<161 2000 32 11255 https://doi.org/10.1023/A:1007110624151 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1007110624151 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leone Aurelio Division of Medicine City Hospital Massa, ASL 1, Massa e Carrara, Italy aut NATIONALLICENCE 700 1- Bertanelli Franco Division of Medicine City Hospital Pontremoli, ASL 1, Massa e Carrara, Italy aut NATIONALLICENCE 700 1- Mori Lino Division of Medicine City Hospital Pontremoli, ASL 1, Massa e Carrara, Italy aut NATIONALLICENCE 773 0- International Urology and Nephrology Kluwer Academic Publishers 32/2(2000-06-01), 161-163 0301-1623 32:2<161 2000 32 11255 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer