caa a22 4500 475774183 CHVBK 20180406123626.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s004180000187 doi (NATIONALLICENCE)springer-10.1007/s004180000187 Subtypes of thymic epithelial cells defined by neuroendocrine markers [Elektronische Daten] [Renata Brelińska, Danuta Ostalska, Maciej Zabel] Abstract.: The study attempted to define characteristics of thymic epithelial cells within rat thymus based on the expression of neuroendocrine markers. Using an immunohistochemical approach, the following markers were localised: protein gene product9.5 (PGP9.5), neuron-specific enolase (NSE) and chromograninA (ChA). It was shown that cells displaying immunostaining typical for individual markers reside in distinct regions of the thymus and represent subtypes within various populations of thymic epithelial cells. An immunoreactivity for PGP9.5 was found exclusively in a subtype of cortical epithelial cells, located mostly within the inner zone of the cortex. On the other hand, NSE represented a marker of most epithelial cells located in the medulla. Few such cells which were negative for NSE proved positive for ChA. Among the cells with a strong reaction for NSE some cells also manifested a positive reaction for ChA. While the pattern of neuroendocrine marker distribution may reflect functional properties of thymic epithelial cells which might be different within distinct areas of the thymus, the differential expression of individual markers seems to reflect biological activity of the cells and/or distinct stages of their differentiation. Springer-Verlag, 2000 Thymic epithelial cells Neuroendocrine markers expression Immunocytochemistry Rat nationallicence Brelińska Renata Department of Histology and Embryology, K. Marcinkowski University of Medical Sciences, ul. Świecickiego 6, Pl-60-781 Poznań, Poland aut Ostalska Danuta Department of Histology and Embryology, K. Marcinkowski University of Medical Sciences, ul. Świecickiego 6, Pl-60-781 Poznań, Poland aut Zabel Maciej Department of Histology and Embryology, K. Marcinkowski University of Medical Sciences, ul. Świecickiego 6, Pl-60-781 Poznań, Poland aut https://doi.org/10.1007/s004180000187 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180000187 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brelińska Renata Department of Histology and Embryology, K. Marcinkowski University of Medical Sciences, ul. Świecickiego 6, Pl-60-781 Poznań, Poland aut NATIONALLICENCE 700 1- Ostalska Danuta Department of Histology and Embryology, K. Marcinkowski University of Medical Sciences, ul. Świecickiego 6, Pl-60-781 Poznań, Poland aut NATIONALLICENCE 700 1- Zabel Maciej Department of Histology and Embryology, K. Marcinkowski University of Medical Sciences, ul. Świecickiego 6, Pl-60-781 Poznań, Poland aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer