caa a22 4500 475774299 CHVBK 20180406123626.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1007/s004180000194 doi (NATIONALLICENCE)springer-10.1007/s004180000194 Laryngeal endocrine cells: topographic distribution and adaptation to chronic hypercapnic hypoxia [Elektronische Daten] [Yoshio Yamamoto, Tatsumi Kusakabe, Yoshiaki Hayashida, Takafumi Yoshida, Hideki Matsuda, Yasuro Atoji, Yoshitaka Suzuki] Abstract.: The morphology, topographic distribution, effects of denervation, and exposure to hypercapnic hypoxia of endocrine cells were examined in rat larynx. The endocrine cells, which were immunoreactive for protein gene product9.5 (PGP9.5) and calcitonin gene-related peptide (CGRP), were observed within the epithelial layer of the laryngeal cavity and in the laryngeal gland, while solitary endocrine cells with apical and/or basal cytoplasmic processes appeared near the glottis. After denervation of the left cervical vagosympathetic trunk and the superior laryngeal nerve, the number of mucosal endocrine cells in the denervated side was not significantly different from that in the intact side. After exposure to hypercapnic hypoxia for 3months, the number of endocrine cells with PGP9.5 and CGRP was markedly increased. In conclusion, the secretion of laryngeal endocrine cells may be stimulated by CO2 rather than O2. Furthermore, the endocrine cells and the sensory and autonomic nervous system may regulate each other by an axon reflex mechanism. Endocrine cells appear to play a very important role in the local regulation of the laryngeal mucosa. Springer-Verlag, 2000 Endocrine cells Larynx Chemoreceptors Superior laryngeal nerve Hypoxia Wistar rat nationallicence Yamamoto Yoshio Laboratory of Veterinary Anatomy, Department of Veterinary Science, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan aut Kusakabe Tatsumi Department of Anatomy, Yokohama City University, School of Medicine, Yokohama 236-0004, Japan aut Hayashida Yoshiaki Department of Systems Physiology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan aut Yoshida Takafumi Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Yokohama, 236-0004, Japan aut Matsuda Hideki Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Yokohama, 236-0004, Japan aut Atoji Yasuro Laboratory of Veterinary Anatomy, Department of Veterinary Science, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan aut Suzuki Yoshitaka Laboratory of Veterinary Anatomy, Department of Veterinary Science, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan aut https://doi.org/10.1007/s004180000194 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180000194 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamamoto Yoshio Laboratory of Veterinary Anatomy, Department of Veterinary Science, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan aut NATIONALLICENCE 700 1- Kusakabe Tatsumi Department of Anatomy, Yokohama City University, School of Medicine, Yokohama 236-0004, Japan aut NATIONALLICENCE 700 1- Hayashida Yoshiaki Department of Systems Physiology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan aut NATIONALLICENCE 700 1- Yoshida Takafumi Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Yokohama, 236-0004, Japan aut NATIONALLICENCE 700 1- Matsuda Hideki Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Yokohama, 236-0004, Japan aut NATIONALLICENCE 700 1- Atoji Yasuro Laboratory of Veterinary Anatomy, Department of Veterinary Science, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan aut NATIONALLICENCE 700 1- Suzuki Yoshitaka Laboratory of Veterinary Anatomy, Department of Veterinary Science, Faculty of Agriculture, Gifu University, Gifu 501-1193, Japan aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer