caa a22 4500 475774345 CHVBK 20180406123626.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s004180000200 doi (NATIONALLICENCE)springer-10.1007/s004180000200 Electron microscopic immunolocalization of basic fibroblast growth factor in peripheral nerves [Elektronische Daten] [Robert J. Kayton, Ranan Gulhan Aktas] Abstract.: In spite of ample information about the distribution and the effects of basic fibroblast growth factor (bFGF) in the central nervous system, few data are available concerning the localization of this protein in the peripheral nervous system. In view of the role of bFGF in the regulation of trophic and non-trophic functions, we focused on the presence and precise localization of this growth factor in normal peripheral nerves at the electron microscopic level. The study shows that bFGF is mainly located in the Schwann cells, especially in the nuclei. There is slight labeling in the myelin sheath and in the axon cytoplasm. The study provides morphologic evidence for an association between bFGF expression and Schwann cells. Such an association argues for a role of this peptide in the maintenance or regeneration of peripheral nerves. Springer-Verlag, 2000 Basic fibroblast growth factor Immunoelectron microscopy nationallicence Kayton Robert J. Oregon Health Sciences University, Center for Research on Occupational and Environmental Toxicology, EM/Histology Core, 3181 SW Sam Jackson Park Road, L606, Portland, OR 97201-3098, USA aut Aktas Ranan Gulhan Faculty of Medicine, Trakya University, Pathology Department, 22030 Edirne, Turkey aut https://doi.org/10.1007/s004180000200 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180000200 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kayton Robert J. Oregon Health Sciences University, Center for Research on Occupational and Environmental Toxicology, EM/Histology Core, 3181 SW Sam Jackson Park Road, L606, Portland, OR 97201-3098, USA aut NATIONALLICENCE 700 1- Aktas Ranan Gulhan Faculty of Medicine, Trakya University, Pathology Department, 22030 Edirne, Turkey aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer