caa a22 4500 475774477 CHVBK 20180406123627.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1007/s004180000172 doi (NATIONALLICENCE)springer-10.1007/s004180000172 Expression of fucosyltransferases in skin, conjunctiva, and cornea during human development [Elektronische Daten] [J.J. Candelier, R. Mollicone, B. Mennesson, P. Coullin, R. Oriol] Abstract.: During human development, type-1-precursor, sialyl-Lea, and Lex antigens were present in the periderm of skin and eye at week6. The Lex antigen disappeared from cornea at 10weeks and then from skin at 20weeks. H-type-1, Lea, Leb, sialyl-Lea, H-type-2, sialyl-Lex, and Ley were found in cornea, conjunctiva, and periderm between 10 and 20weeks. They disappear from the skin (at week20) and progressively reappear in skin derivatives, especially in the epithelium of sweat glands. The secretory part of the sweat gland is type-1-precursor and H-type-1 positive while its excretory part is Lea, Leb, sialyl-Lea, and Ley positive. On the eye surface the disappearance of Lex at 10weeks and of the H-type-1, sialyl-Lex, and Ley at week35 starts in the central cornea in front of the lens. The corneal epithelium and the conjunctiva have similar antigens to those of excretory and secretory parts of the sweat gland, respectively. Invaginations and folding of the epidermis might preserve the embryonic staining. We propose that fucosylation patterns are associated with the embryonic origin and differentiation stage of tissue. The early and transient presence of Lex is associated with FUT4 or FUT9 activities, while the late appearance of Lewis antigens is related to other α3-fucosyltransferases. Springer-Verlag, 2000 Cornea Fucosyltransferase Human development Lewis antigens Skin nationallicence Candelier J.J. INSERM U504, 16 Avenue Paul Vaillant-Couturier, 94807 Villejuif cedex, France aut Mollicone R. INSERM U504, 16 Avenue Paul Vaillant-Couturier, 94807 Villejuif cedex, France aut Mennesson B. Hôpital de Pontoise, 95300 Pontoise, France aut Coullin P. UMR 1599 CNRS. Cytogénétique, IGR Villejuif 94805, France aut Oriol R. INSERM U504, 16 Avenue Paul Vaillant-Couturier, 94807 Villejuif cedex, France aut https://doi.org/10.1007/s004180000172 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180000172 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Candelier J.J. INSERM U504, 16 Avenue Paul Vaillant-Couturier, 94807 Villejuif cedex, France aut NATIONALLICENCE 700 1- Mollicone R. INSERM U504, 16 Avenue Paul Vaillant-Couturier, 94807 Villejuif cedex, France aut NATIONALLICENCE 700 1- Mennesson B. Hôpital de Pontoise, 95300 Pontoise, France aut NATIONALLICENCE 700 1- Coullin P. UMR 1599 CNRS. Cytogénétique, IGR Villejuif 94805, France aut NATIONALLICENCE 700 1- Oriol R. INSERM U504, 16 Avenue Paul Vaillant-Couturier, 94807 Villejuif cedex, France aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer