caa a22 4500 475774523 CHVBK 20180406123627.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004180050001 doi (NATIONALLICENCE)springer-10.1007/s004180050001 On the molecular architecture of myelinated fibers [Elektronische Daten] [E. J. Arroyo, S. S. Scherer] Abstract : Schwann cells and oligodendrocytes make the myelin sheaths of the PNS and CNS, respectively. Their myelin sheaths are structurally similar, consisting of multiple layers of specialized cell membrane that spiral around axons, but there are several differences. (1) CNS myelin has a ”radial component” composed of a tight junction protein, claudin-11/oligodendrocyte-specific protein. (2) Schwann cells have a basal lamina and microvilli. (3) Although both CNS and PNS myelin sheaths have incisures, those in the CNS lack the structural as well as the molecular components of ”reflexive” adherens junctions and gap junctions. In spite of their structural differences, the axonal membranes of the PNS and CNS are similarly organized. The nodal axolemma contains high concentrations of voltage-dependent sodium channels that are linked to the axonal cytoskeleton by ankyrinG. The paranodal membrane contains Caspr/paranodin, which may participate in the formation of axoglial junctions. The juxtaparanodal axonal membrane contains the potassium channels Kv1.1 and Kv1.2, their associated β2 subunit, as well as Caspr2, which is closely related to Caspr. The myelin sheath probably organizes these axonal membrane-related proteins via trans interactions. Springer-Verlag Berlin Heidelberg, 2000 Arroyo E. J. Department of Neurology, Room 460 Stemmler Hall, 36th Street and Hamilton Walk, The University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA e-mail: scherer@mail.med.upenn.edu Tel.: +1-215-5733198, Fax: +1-215-573-2029, US aut Scherer S. S. Department of Neurology, Room 460 Stemmler Hall, 36th Street and Hamilton Walk, The University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA e-mail: scherer@mail.med.upenn.edu Tel.: +1-215-5733198, Fax: +1-215-573-2029, US aut https://doi.org/10.1007/s004180050001 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180050001 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arroyo E. J. Department of Neurology, Room 460 Stemmler Hall, 36th Street and Hamilton Walk, The University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA e-mail: scherer@mail.med.upenn.edu Tel.: +1-215-5733198, Fax: +1-215-573-2029, US aut NATIONALLICENCE 700 1- Scherer S. S. Department of Neurology, Room 460 Stemmler Hall, 36th Street and Hamilton Walk, The University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA e-mail: scherer@mail.med.upenn.edu Tel.: +1-215-5733198, Fax: +1-215-573-2029, US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer