caa a22 4500 475774566 CHVBK 20180406123627.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s004180050003 doi (NATIONALLICENCE)springer-10.1007/s004180050003 The expression of androgen receptors in human neck and limb muscles: effects of training and self-administration of androgenic-anabolic steroids [Elektronische Daten] [F. Kadi, P. Bonnerud, A. Eriksson, L. -E. Thornell] Abstract : The purpose of this study was to investigate the immunohistochemical expression of androgen receptors (AR) in human vastus lateralis and trapezius muscles and to determine whether long-term strength training and self-administration of androgenic-anabolic steroids are accompanied by changes in AR content. Biopsy samples were taken from eight high-level power-lifters (P), nine high-level power-lifters who used anabolic steroids (PAS) and six untrained subjects (U). Myonuclei and AR were visualised in cross-sections stained with the monoclonal antibody against AR and 4',6-diamidino-2-phenylindole. The proportion of AR-containing myonuclei per fibre cross-section was higher in the trapezius than in the vastus lateralis (P<0.05). In the trapezius, the proportion of AR-containing myonuclei was higher in P compared to U and in PAS compared to both P and U (P<0.05). On the contrary, in the vastus lateralis, there were no differences in AR content between the three groups. Myonuclear number in both muscles was higher in P compared to U and in PAS compared to both P and U (P<0.05). In conclusion, AR content differs greatly between human neck and limb muscles. Moreover, the regulation of AR-containing myonuclei following training and self-administration of androgenic-anabolic steroids is muscle dependent. Springer-Verlag Berlin Heidelberg, 2000 Kadi F. Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut Bonnerud P. Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut Eriksson A. Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut Thornell L. -E Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut https://doi.org/10.1007/s004180050003 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s004180050003 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kadi F. Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut NATIONALLICENCE 700 1- Bonnerud P. Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut NATIONALLICENCE 700 1- Eriksson A. Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut NATIONALLICENCE 700 1- Thornell L. -E Department of Integrative Medical Biology, Section for Anatomy, Umeå University, 901 87, Umeå, Sweden e-mail: fawzi.kadi@anatomy.umu.se Tel.: +46-90-7865122 Fax: +46-90-7865480, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer